Contents 1 Pinyin 2 English reference 3 Overview 4 Composition 5 Effects and indications of Guchong decoction 6 Usage and dosage of Guchong decoction 7 Prescriptions and explanations 8 Clinical application of Guchong decoction 8.1 Addition and subtraction 8.2 Contraindications 8.3 Guchong decoction treats hemorrhage 8.4 Guchong decoction treats functional uterine bleeding 9 Modern indications of Guchong decoction 9.1 Functional uterine bleeding 10 Pharmacological effects of Guchong decoction 10.1 Effects on the functions of the nervous and endocrine systems 10.2 Effects on bleeding, uterus and reproduction Functional impact 10.3 Impact on heart, blood vessels and blood rheology 10.4 Impact on digestive system function 10.5 Impact on immune function and antioxidant damage 11 Song 12 Source 13 References attached: 1 Guchong Tang in ancient books 1 Pinyin
gù chōng tāng 2 English reference
guchong decoction [Traditional Chinese Medicine Terminology Approval Committee. Traditional Chinese Medicine Terminology (2004)]
Guchong Tang [21st Century Bilingual Science and Technology Dictionary] 3 Overview
Guchong Decoction is recorded in the first volume of "Medicine Zhongshen Xilu". It consists of 30g of Atractylodes macrocephala (fried), 18g of raw astragalus, 24g of calcined dragon bone, 24g of calcined oyster, and cornus root. 24g of meat, 12g of raw peony root, 12g of jellyfish, 9g of madder, 6g of palm charcoal, and 1.5g of gallnut. It has the effect of solidifying blood, replenishing qi and strengthening the spleen. It mainly treats spleen and kidney deficiency and Chongmai failure syndrome. This prescription is a commonly used prescription for treating deficiency of the spleen and kidneys, hemorrhage and menorrhagia caused by weak Chongmai. In modern times, it is often used for patients with functional uterine bleeding, excessive postpartum bleeding, etc. who have weak spleen and kidneys and are not stable in charge and responsibility.
Guchong decoction has a powerful neurological and endocrine regulatory effect, especially for the regulation of sex hormones such as estrogen. It has a powerful hemostatic effect on uterine bleeding, thus affecting the function of the uterus. Sexual uterine bleeding should have some therapeutic effect. At the same time, through analysis of the prescription, it was also found that it has a certain promoting effect on cardiovascular and blood rheology, immune function, digestive system function, etc. At the same time, most drugs also have anti-pathogenic microbial effects. Since they are not the focus of this section’s analysis, they will not be described in detail. [1] 4 Composition
One liang of Atractylodes macrocephala (fried), 6 qian of raw astragalus, 8 qian of dragon bone (forged and pounded into fine pieces), 8 qian of oysters (forged and pounded into fine pieces), 8 qian of cornus root (removed and pitted) ), 4 qian of raw Hangzhou peony, 4 qian of sea octopus (pounded finely), 3 qian of madder, 2 qian of brown edge charcoal, 5 qian of gallnut (pulverized finely) [2]
Atractylodes macrocephala (stir-fried) 30g , raw astragalus 18g, calcined keel 24g, calcined oyster 24g, cornus 24g, raw peony root 12g, sea octopus 12g, madder 9g, palm charcoal 6g, gallnut 1.5g[3]
Atractylodes macrocephala ( Stir-fried) 30g raw astragalus 18g keel (forged and pounded finely) 24g oysters (forged and pounded finely) 24g cornus (remove the core) 24g raw peony root 12g sea octopus (pounded finely) 12g madder 9g brown edge charcoal 6g
Atractylodes 1 tael (fried), raw astragalus 6 qian, dragon bone 8 qian (forged, pounded fine), oyster 8 qian (forged, pounded fine), cornus 8 qian Qian (removed and cored), 4 qian of raw peony root, 4 qian of jellyfish (pounded finely), 3 qian of madder, 2 qian of brown edge charcoal, 5 qian of gallnut (pulverized into fine pieces, and the concoction is taken). 5 Effects and Indications of Guchong Decoction
Guchong Decoction has the effects of Guchong Decoction, invigorating blood, replenishing qi and strengthening the spleen. It mainly treats spleen and kidney deficiency and Chongmai failure syndrome. Symptoms include sudden hemorrhage or menorrhagia, or persistent menstruation, light color and thin texture, dizziness, cold limbs, palpitations, shortness of breath, mental fatigue, weak waist and knees, pale tongue, and weak pulse. [3] 6 Usage and dosage of Guchong Tang
Take the medicinal juice [2]
Add the medicine and decoct the soup, and kimono with 15 grams of gallnut powder.
If the pulse is hot, add 30 grams of Radix Rehmanniae; if the pulse is cold, add 9 grams of Aconite. 7 Recipes
Guchong Decoction is mainly used to treat metrorrhagia due to kidney deficiency, spleen deficiency, and slippage of the Chongmai. The symptoms should be treated urgently. The main treatment is to use Guchong to absorb blood and strengthen the spleen. Qi is the supplement. Cornus officinale is used heavily in the prescription, which is sweet, sour and warm. It can not only nourish the liver and kidneys, but also astringe and fix astringency. It is a king medicine. Dragon bone tastes sweet and astringent, while oysters are salty and astringent. They are used together to astringe vitality and cure astringency and slippage. It is a royal medicine that can help cure astringency and slippage. Atractylodes nourishes qi and strengthens the spleen to help improve transportation and control. Astragalus is good at nourishing qi and lifting. , especially good at treating miscarriage and metrorrhagia. The two medicines are used together to make the spleen strong and have the power to control, and the aphrodisiac is the ministerial medicine. Raw white peony root is sour and astringent, and has the function of nourishing the liver and kidneys, nourishing blood and astringing yin; palm charcoal and gallnut are astringent and astringent, good at astringent and stopping bleeding; jellyfish and madder can fix the lower burnt, which can stop bleeding, remove blood stasis, and stop bleeding. Without the disadvantage of leaving blood stasis, the above ingredients are used as adjuvants. When all medicines are used together, they can be used to strengthen the blood, replenish qi and strengthen the spleen. [3]
It rushes into the sea of ??blood, and the spleen is the source of qi and blood biochemistry. It governs and absorbs blood.
If the spleen is weak, there is no control over it, or the Chong meridians are not solid, resulting in bleeding or menorrhagia. It is urgently advisable to replenish qi and strengthen the spleen, and strengthen the blood to cure it. Atractylodes macrocephala and astragalus are used heavily in the prescription to replenish qi and strengthen the spleen. When the spleen is strong, it can control and control the spleen, so it is a monarch medicine. The liver is in charge of the sea of ??blood, and the kidneys are in charge of Chong and responsibilities. Therefore, cornus and raw white peony root are used to nourish the liver and kidneys, nourish blood and restrain yin, and use anesthesia as ministerial drugs. Forged keel bones, calcined oysters, palm charcoal, and gallnuts are used to reduce astringency and stop bleeding; in the brigade's astringent-fixing medicine, sea octopus and madder are also used to remove blood stasis and stop bleeding, which can stop bleeding without leaving blood stasis. The above medicines are used as adjuvants. Comprehensive comprehensive prescription, invigorating Qi and strengthening Chong to treat the root cause, reducing astringency and stopping bleeding to treat the symptoms, and finally playing the role of consolidating collapse and stopping bleeding. [4] 8 Clinical Application of Guchong Decoction
Guchong Decoction is a commonly used prescription for treating spleen and kidney deficiency, hemorrhage and menorrhagia caused by weak Chongmai. Clinically, the key points of syndrome and treatment are heavy bleeding, light color and thin texture, soreness and weakness of waist and knees, pale tongue, and weak pulse. [3] 8.1 Addition and subtraction
If you have cold sweats in your limbs and a weak pulse, it is a sign of Yang Qi deficiency and want to escape. It is necessary to increase the dosage of Astragalus and combine it with Shenfu Decoction to replenish Qi and restore Yang. . [3] If the pulse is hot, add 1 tael of Radix Rehmanniae; if the pulse is cold, add 3 qian of Wu Fuzi; if the pulse is violent and the blood collapses due to liver qi, add 2 qian of Bupleurum; if the medicine does not heal after two doses, remove the brown edge charcoal. , add 5 qian of real donkey-hide gelatin (stewed separately) and take together; if you feel internal heat after taking the medicine, add raw rehmannia. 8.2 Contraindications for use
People with blood heat and uterine bleeding should avoid using Guchong Decoction [3]. 8.3 Guchong Decoction treats hemorrhagic collapse
A woman in her thirties suddenly started bleeding for two days. Upon examination, he was unconscious and speechless, his whole body was cold, and his pulse was weak and slow. It is known that the Qi and blood will be lost, and the Yuanyang will also be lost. So I quickly used this soup to remove the white peony root, and added eight qian of wild Taiwan ginseng and three qian of black monkshood. One dose stops the bleeding, the whole body becomes warm, and the spirit returns. Still add the white peony root and take another dose to ease the aftermath. 8.4 Guchong Decoction for the treatment of functional uterine bleeding
Fifty cases of functional uterine bleeding were treated with Guchong Decoction, one dose per day, and three days as a course of treatment. Among them, for the strain type (30 cases), red ginseng, Panax notoginseng, and deer horn cream were added; for the deficiency-cold type (14 cases), Futang, Paojiang, and mugwort leaves were added; for the deficiency-heat type (4 cases), rehmannia glutinosa, paeonol bark, and Eclipta were added. , for blood stasis type (2 cases), add Puhuang, red peony root and angelica root. As a result, after 12 courses of treatment, 34 cases were cured, 13 cases were markedly effective, and 3 cases were effective. 9 Modern indications of Guchong Decoction
[4]
Patients with functional uterine bleeding who have weak spleen and weak Chong and Ren can use Guchong Decoction. 9.1 Functional uterine bleeding
Functional uterine bleeding includes two types: ①Anovulatory dysfunctional uterine bleeding is caused by the body being affected by internal or external factors such as mental stress, metabolic disorders, sudden changes in climate, etc. , causing menstrual disorders through abnormal regulation of hypothalamic-pituitary-ovarian axis function or target cell effects caused by the cerebral cortex and central nervous system. The main manifestations of endometrium are: increased tissue fragility, incomplete endometrial shedding and difficulty in repair, abnormal blood volume structure and function, abnormal coagulation and fibrinolysis. The clinical manifestations are disordered menstrual cycles, varying lengths of menstrual periods, and irregular menstrual flow. Even heavy bleeding. ② Ovulatory menstrual disorder is due to follicular development and ovulation during the menstrual cycle, but insufficient secretion of progesterone in the luteal phase or premature decline of the corpus luteum, resulting in poor endometrial secretion response. The main pathology is poor secretion of endometrial glands. Interstitial edema is not obvious or glands and interstitial development are not synchronized, and the main clinical manifestation is shortened menstrual cycle. The other is due to the dysfunction of the thalamus-pituitary-ovary axis or abnormal luteolytic mechanism, which causes luteal insufficiency, leading to irregular shedding of the endometrium. The main clinical manifestations are prolonged menstrual cycle, which lasts for 9 to 10 days, and bleeding. A lot of quantity. 10 Pharmacological effects of Guchong decoction
[5] 10.1 Effects on the functions of the nervous and endocrine systems
Astragalus decoction can enhance learning and memory consolidation, and also has central sedation , analgesic effect; Astragalus can significantly increase cerebral blood flow, and can also regulate central neuropeptides, renin-angiotensin-aldosterone system and kinin system, thereby lowering blood pressure; Astragalus can inhibit the release of catecholamines in the brain due to hypoxia Elevated, protecting the brain due to hypoxia, resulting in a decrease in ATP content and oxidative phosphorylation in the brain; Astragalus polysaccharide can significantly resist the hyperglycemic response of epinephrine, and has a significant antagonistic effect on hypoglycemia caused by phenformin. Recent studies have proven that astragalus polysaccharide It has an obvious hypoglycemic effect and has a good therapeutic effect on diabetic patients. Intraperitoneal injection of astragalus polysaccharide shows a significant increase in the weight of the adrenal glands of mice. Continuous administration of astragalus decoction shows a significant increase in the lipid vacuole content of the adrenal zona cells of rats, and It can significantly inhibit the reduction of exhausted plasma cortisol content, thereby further improving its anti-inflammatory, antipyretic, permissive effects, and regulating effects on nerve and endocrine functions; there are also studies proving that astragalus has an estrogen-like effect. Atractylodes has a sedative effect, can enhance adrenal cortex function, has anti-stress effects, enhances physical strength, and has a hypoglycemic effect. Cornus cornus, a ministerial drug, can excite parasympathetic nerves, enhance pituitary-adrenocortical function, increase cortisol concentration, and have the effects of anti-stress, anti-hypoxia, anti-fatigue, and enhance memory function; cornus can also promote residual The secretory function of pancreatic beta cells and the promotion of tissue utilization of glucose have a hypoglycemic effect.
White peony has central sedative, analgesic and anticonvulsant effects, and can enhance learning and memory abilities, improve hypoxia tolerance, improve brain electrical activity caused by hypoxia, and reduce brain calcium, sodium, and water content; total glycosides of white peony It has an obvious protective effect on the highly excited hypothalamus-pituitary-adrenal axis, and at the same time has a biphasic regulatory effect on it; the aqueous extract of white peony root contains a component that antagonizes the octapeptide cholecystokinin receptor on pancreatic acinar cells, and can also Treat central or peripheral muscle spasm, as well as abdominal pain caused by spasm. The adjuvant medicines keel, oysters, jellyfish and the royal medicine astragalus contain large amounts of calcium carbonate, calcium phosphate and calcium sulfate, as well as magnesium, aluminum, silicon, iron oxide, calcium oxide, potassium, sodium, chlorine, copper, zinc, Magnesium, strontium, nickel, titanium, phosphorus, manganese and other trace elements. A large amount of Ca2+ reduces the excitability of neuromuscular and plays an important role in the conduction of nerve impulses, muscle contraction and neuromuscular stress. When Mg2+ is deficient, the nerves Impairments in muscle conduction regulation will occur. Mg2+ combines with mitochondria in cells and plays a cofactor role in many enzymes, especially in the activation and production of ATP and cAMP, neuromuscular conduction regulation, and the stability of intracellular potassium and calcium. play an important role. Potassium is an activator of enzymes related to sugar oxidation, ATP production, and glycogen synthesis. When potassium is lacking, ATP production is insufficient. Potassium can activate acetylase. Potassium deficiency affects the synthesis of neuromediators such as acetylcholine and affects neuromuscular excitation. sex. Sodium directly affects the transmission of nerve impulses and neuromuscular stress. Iron can treat iron deficiency anemia. Clinically, patients with iron deficiency anemia are often seen to be irritable and have difficulty concentrating. This is because iron deficiency reduces the activity of monoamine oxidase in the brain, reduces serotonin, and increases the excretion of norepinephrine in the urine. Caused by; return to normal after iron treatment, indicating that iron has a certain regulatory effect on neurological function. When copper is deficient, mental development disorders improve after copper treatment, indicating that copper has a certain effect on the central nervous system; copper has enzyme and hormone-like catalytic effects. For example, adding a small amount of copper salt to the diet of diabetic patients will improve the patient's general condition, urine sugar, and Blood sugar decreases. It can be seen that the above-mentioned substances contained in keels and oysters can play an important regulatory role in the nervous and endocrine systems from a molecular biology perspective. The gallic acid contained in gallnuts has a precipitating effect on proteins. The proteins in gland cells are coagulated, causing secretion inhibition, resulting in dry mucous membranes and protein precipitation in nerve endings, which can cause weak local anesthesia. Rubia extract can increase the ATP content in the brain, which is beneficial to energy metabolism and oxygen effect regulation.
It can be seen that this prescription has certain regulating and promoting effects on brain function, hypothalamic-pituitary-adrenocortical axis and various endocrine systems, which is the main cause of functional uterine bleeding - nerves. Sex hormone dysregulation should have some benefit. 10.2 Effects on bleeding, uterine and reproductive functions
The royal medicine Astragalus has an estrogen-like effect, which is beneficial to maintaining female secondary sexual characteristics and, in conjunction with progesterone, causes the endometrium to cycle Sexual changes, formation of menstrual cycle, enhanced sensitivity of uterine smooth muscle to oxytocin, hyperplasia of vaginal epithelium, oxidation of superficial cells, and can also act on the hypothalamic-pituitary system by inhibiting GnRH (gonadotropin-releasing hormone) Release to inhibit ovulation. The alcohol or petroleum ether extract of Atractylodes macrocephala, a royal medicine, has a significant inhibitory effect on the spontaneous contraction of the uterus or the excitatory contractions of the uterus caused by oxytocin and motherwort. However, the effect of the water extract of Atractylodes macrocephala is weaker than that of the alcohol extract. The ministerial drug white peony has an antispasmodic effect and can significantly inhibit uterine contractions caused by oxytocin. The adjuvant medicines: roasted keel bones, roasted oysters, and sea oysters contain a large amount of calcium and phosphorus, which participate in the coagulation process together with the calcium and phosphorus in plasma. Ca2+ is coagulation factor VI, which plays a role in activating factors IX, X, XIII and coagulation. It is indispensable in the process of zymogen; the main components of platelet factor 3 and coagulation factor IV are phosphorus, both of which play a key role in the coagulation reaction of the coagulation process. The alcohol extract of adjuvant palm seed powder can contract the uterus and has coagulation effect. The hemostatic pills made from it are good for uterine bleeding caused by functional uterine bleeding, uterine fibroids, chronic cervicitis and other reasons. hemostatic effect. The n-butanol extract of Rubia aqueous extract is the active component of the drug's hemostatic activity. It promotes the three stages of the coagulation process, namely thromboplastin generation, thrombin generation, and fibrin formation. Clinically, Rubia powder and gauze are used. Applying pressure to the femoral artery for 35 seconds can stop bleeding. Each medicine in this prescription contains a large amount of biological agents, proteins, and amino acids. Oysters, keels, and sea octopuses contain large amounts of calcium, magnesium, iron, zinc, potassium, and sodium. Calcium itself is an important coagulation factor. Cornus officinalis and gallnut contain a large amount of gallic acid, which can form insoluble compounds with certain metals and biological alkaloids, thus having detoxification and astringent effects; after gallic acid comes into contact with proteins in skin, mucous membranes and various tissues, tissue proteins are coagulated , forms a kind of film and has astringent and hemostatic effect. Madder, dogwood and gallnut contain large amounts of tannins, which also have astringent and hemostatic effects. Each medicine in this prescription contains a large amount of vitamins, especially vitamin A, etc., which lays a favorable foundation for the repair of uterine mucosa.
It can be seen that this prescription has strong hemostatic and antispasmodic effects, so it can relieve bleeding and pain.
10.3 Effects on the heart, blood vessels and blood rheology
Astragalus decoction can inhibit the activity of phosphodiesterase (PDE), thereby increasing the amount of cAMP and activating cAMP-dependent protein kinase, resulting in The phosphorylation of calcium channel proteins leads to an increase in calcium influx; at the same time, the increase in intracellular cAMP also promotes the release of calcium from the sarcoplasmic reticulum, leading to the enhancement of the excitation-contraction coupling process of cardiomyocytes, thereby enhancing myocardial contractility and increasing cardiac output. It has a more obvious effect on the heart caused by poisoning and fatigue; Astragalus can protect the myocardium through various ways, increase coronary blood flow, promote myocardial metabolism, enhance the tolerance of myocardial cells to injury, and reduce myocardial consumption. oxygen, reduce the oxidative phosphorylation rate in mitochondria and have an uncoupling effect; Astragalus can also increase the content of 2,3-glycerol diphosphate in red blood cells, enhance the oxygen transport capacity of hemoglobin, increase the SOD content in red blood cells, and resist free radicals, thereby playing a role in To protect the myocardium; Astragalus polysaccharide has a significant protective effect on myocardial ischemia caused by pituitary hormone, and also has an anti-arrhythmic effect; in addition to its direct vasodilatory effect, Astragalus can also regulate central neuropeptides, renin-vascular tension It can lower the blood pressure of hypertensive animals, raise and maintain stable blood pressure of hypotensive or shock animals, and at the same time improve microcirculation; Astragalus has a very strong effect on calmodulin. It has a significant inhibitory effect, thereby inhibiting the activity of phosphodiesterase, reducing the hydrolysis of cAMP in platelets and increasing its content. It can also regulate arachidonic acid metabolism, inhibit the production of TXA2, and promote the production of PGI2, thus reducing blood viscosity. Inhibit platelet aggregation and prevent thrombosis. Atractylodes has a dilating effect on blood vessels, a mild inhibitory effect on the heart, and a significant prolongation of prothrombin time and coagulation time. Cornus officinalis can rapidly and significantly increase blood pressure in hemorrhagic shock and has an anti-shock effect; it can enhance myocardial contractility, increase heart pumping volume and expand peripheral blood vessels, inhibit platelet aggregation and anti-thrombosis, and is beneficial to relieving the symptoms of hemorrhagic shock. Shock and DIC formation play a certain role. White peony root can dilate coronary arteries, increase myocardial nutritional blood flow, and at the same time expand peripheral blood vessels, lowering blood pressure; it can inhibit platelet aggregation and thrombosis. Rubia extract Rubia II can increase coronary blood flow and reduce the scope of myocardial infarction, reduce platelet aggregation, prolong hypoxia tolerance time, and antagonize myocardial ischemia caused by pituitaryin. Keels, oysters, and octopuses contain a large amount of trace elements such as calcium, magnesium, iron, and zinc. When blood Ca2+ is low, the barrier effect on the Na+ inflow of myocardial cells is reduced, which increases myocardial excitability and conductivity. However, due to the membrane The concentration difference between internal and external Ca2+ decreases, and the Ca2+ inflow slows down, which prolongs the action potential plateau phase and the refractory period. Oysters can supplement Ca2+, so they are beneficial to the elimination of this situation. At the same time, Ca2+ is also beneficial to the generation of coagulation factors, Therefore, it has a procoagulant effect; hypomagnesemia can have serious adverse effects on cardiovascular disease. First, hypomagnesemia can cause the Na+K+ pump to malfunction, leading to an increase in myocardial excitability; Mg2+ has a blocking effect on Na+, causing Increased autonomic rhythm of myocardial cells, low Mg2+ is often accompanied by low K+, which can aggravate the above two conditions and cause arrhythmia. Arrhythmia can also cause patients to be irritable and spontaneously sweat; secondly, low Mg2+ can cause vasoactive endothelin , the production of catecholamines increases, and the production of prostacyclin that dilates blood vessels decreases, which increases blood pressure and peripheral resistance, thereby causing spontaneous sweating; Mg2+ is an essential cofactor for many enzyme systems, and severe reduction of Mg2+ can cause metabolic disorders of myocardial cells and coronary vasculature. Spasm is a risk factor for myocardial infarction. Oysters contain a large amount of Mg2+, which can improve the above situation. 10.4 Impact on the function of the digestive system
Astragaloside and polysaccharides contained in the royal medicine Astragalus have significant hepatoprotective effects. Astragaloside has anti-oxidation effects and can induce liver enzymes and make liver cell microsomes The content of cytochrome P450 is significantly increased, which can resist the hemolysis of red blood cells caused by polygala saponins, indicating that it has hepatoprotective function through metabolic regulation and membrane stabilization. Patients with chronic hepatitis B have cellular immune dysfunction, and astragalus injection can make patients CD8 decreases and CD4/CD8 increases, restoring normal immune function, improving the ability to clear viruses and inhibit virus spread; astragalus polysaccharide also has anti-oxidative effects, and can promote the recovery of ATP and has a hepatoprotective effect, can reduce gastric acid secretion, and reduce Pepsin activity significantly reduces serum gastrin and has an anti-gastric ulcer effect. It has a significant inhibitory effect on gastric mucosal damage, reduces the damage index, and reduces the damage area. Atractylodes, the main component of Atractylodes, can inhibit the increase in transaminases, prevent the reduction of liver glycogen, and prevent fat infiltration and tissue necrosis; the ethyl acetate extract of Atractylodes has a choleretic effect; Atractylodes decoction has a biphasic regulatory effect on the intestines. Under normal circumstances, there is Excitatory effect: when the intestine is excited by acetylcholine, Atractylodes macrocephala inhibits it; when it is inhibited by epinephrine, Atractylodes macrocephala excites it, thereby restoring intestinal activity to normal; Atractylodes macrocephala water extract has anti-ulcer effect; Atractylodes macrocephala acetone The extract can inhibit gastric juice secretion, inhibit pepsin activity, and have a protective effect on gastric mucosal damage. Cornus officinalis has anti-liver damage effect and can significantly reduce ALT and AST.
The ministerial drug white peony has a significant protective effect on a variety of experimental liver injury models. It can inhibit the increase in transaminase, resist eosinophilic degeneration and necrosis of liver tissue, and also has a protective effect on immune liver injury. The total paeony glycosides contained in white peony and Peony phenol all has anti-ulcer effects, and white peony root and paeoniflorin have significant antispasmodic effects on the intestines. As an adjuvant, keel bones, oysters, and sea oysters contain a large amount of calcium hydrogen phosphate and calcium phosphate, which can neutralize hydrochloric acid and inhibit hyperacidity in the stomach. They contain a large amount of tannins, cutin, etc., which have a protective effect on the gastric mucosa. In particular, calcined oysters can Significantly lowers the pH value of gastric juice, inhibits gastric juice secretion, and has anti-ulcer effects. Sea octopus can lower the pH value of gastric juice, reduce pepsin activity, and promote the absorption of inflammation on the ulcer surface. The organic matter contained in it forms a protective film after interacting with the organic matter in the stomach, and has anti-ulcer effects. The gallic acid contained in gallnuts combines with protein to prevent gastric bleeding, and combines with calcium and other metals to prevent poisoning.
These effects fully demonstrate that this prescription can promote and protect liver function and gastrointestinal function. 10.5 Effect on immune function and anti-oxidative damage effect
The royal medicine Astragalus membranaceus and the astragalus polysaccharide, astragalus saponin A and other components it contains have extensive immune-enhancing and regulating effects on the immune system. Astragalus injection can significantly prevent and treat the decrease in peripheral blood WBC and bone marrow megakaryocyte count caused by cyclophosphamide, promote the random movement and chemotactic movement of peripheral blood neutrophils, and astragalus polysaccharide can increase the weight of the spleen and significantly antagonize prednisone. atrophy of the spleen, thymus, and lymph nodes caused by Long et al.; Astragalus decoction can significantly promote the phagocytic activity of macrophages. Astragalus saponin A can increase the size of macrophages, and their phagosomes, lysosomes, ribosomes, and rough surface Most organelles such as the plasma reticulum increase in number and are in an activated state; astragalus saponin A can also promote the function of the macrophage enzyme protein synthesis system and promote lysosome synthesis; astragalus promotes the activity of NK cells by inducing stemonin, which can significantly Promote the production of specific antibodies in the normal body, significantly increase the number of antigen-binding cells, antibody-secreting cells, hemolytic plaques and antibody production, and exert a biphasic regulatory effect on antibody-forming cells, promoting those with low responses and those with enhanced responses. If it is inhibited, astragalus can promote T cell differentiation and maturation, increase the T lymphocyte subpopulations CD3, CD4, and CD8 to a level close to normal, and significantly increase their activity. Atractylodes polysaccharide can promote the transformation of lymphocytes, significantly increase the secretion level of IL2, resist the inhibitory effect of hydrocortisone, extend the life of lymphocytes, and correct the disordered distribution of T cell subpopulations; Atractylodes can activate the reticuloendothelial system and enhance its The phagocytosis function significantly increases the phagocytosis percentage, phagocytosis index, and lysosomal digestibility of macrophages, and has the effect of increasing white blood cells. Cornus officinalis decoction can significantly promote the humoral immune function and rapidly form serum IgG and IgM; inhibit the function of reticuloendothelial cells and inhibit the growth of NK cells; enhance the function of people with low immune function and reduce the function of people with hyperimmune function, thus making Immune function is restored to balance. The ministerial drug white peony root has a biphasic regulatory effect on humoral immunity, cellular immunity, and non-specific immunity, that is, the function of the macrophage system. The adjuvant medicine madder can improve cellular immune function and increase white blood cells. Sea turtles, keel bones, and oysters contain large amounts of trace elements calcium, magnesium, iron, zinc, selenium, etc., which are indispensable for the production of immune substances. elements, indicating that this prescription has immune promotion and immune regulation effects; at the same time, keel can significantly increase the weight of the spleen and thymus, and promote macrophage function.
The royal medicine Astragalus decoction can significantly increase the SOD activity of red blood cells and myocardium, has a good scavenging effect on oxygen free radicals, inhibits the increase of peroxidized lipids, and has anti-free radical damage and anti-lipid properties. Peroxidation. Atractylodes can reduce lipid peroxides, reduce the content of LPO and MDA, increase the activity of SOD and GSHPx in the blood, and increase the ability to scavenge oxygen free radicals. The ministerial drugs, total glucosides of paeony and paeony glucosides, have scavenging effects on oxygen free radicals and hydroxyl free radicals, and can inhibit the damage of cells caused by H2O2, so they have antioxidant effects. Rubia root decoction is beneficial to the regulation of energy metabolism and oxygen effects. Human body surface area calculator BMI index calculation and evaluation Female safe period calculator Pregnancy date calculator Normal weight gain during pregnancy Safety classification of medication during pregnancy (FDA) Five elements and eight characters Adult blood pressure evaluation Body temperature level evaluation Diabetes diet recommendations Common clinical biochemistry units Conversion to basal metabolic rate Calculate sodium supplementation calculator Iron supplementation calculator Commonly used Latin abbreviations for prescription Quick check Common symbols for pharmacokinetics Quick check Effective plasma osmolarity calculator Ethanol intake calculator
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The Guchong decoction can be used internally to treat qi, Long Mu Pao Qian and Cornus officinalis; the combination of five flavors, sea octopus, brown charcoal, etc. can always cure collapse and leakage.
[3] 12 Source