What does premature ovarian failure mean?

Premature ovarian failure (POF) refers to ovarian failure caused by various reasons before the age of 40. The incidence rate of POF among women of childbearing age is over 65438 0%, and the incidence rate is increasing and younger in recent years, which is considered as an "incurable disease" leading to infertility. Sun Haixiang, director of the Reproductive Medicine Center of Nanjing Gulou Hospital, told the reporter that patients with premature ovarian failure, even through assisted reproductive technology, are difficult to conceive, because such patients have no dominant follicular activity during the menstrual cycle and cannot obtain eggs.

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Supported by the pilot project of stem cell and regenerative medicine of China Academy of Sciences, the Reproductive Medicine Center of Nanjing Gulou Hospital cooperated with Dai Jianwu's research team of regenerative medicine of Institute of Genetics and Development of China Academy of Sciences, and took the lead in the international clinical study of umbilical cord mesenchymal stem cells intervening premature ovarian failure complicated with infertility on 20 15. After passing the hospital ethics review and filing by the National Health and Family Planning Commission, the clinical research became one of the first eight stem cell clinical research projects in China after the implementation of the stem cell clinical research filing system, and was officially launched in Nanjing Gulou Hospital.

According to the relevant person in charge of Gulou Hospital, the clinical team of professors from Reproductive Center of Nanjing Gulou Hospital performed stem cell ovarian transplantation for Ms. Fang on 20 15+02. Umbilical cord mesenchymal stem cells were prepared by GMP-level clinical stem cell room of Gulou Hospital, and tested by the Third Party Research Institute of US Food and Drug Administration in China. The ovarian blood flow improved significantly after operation. From 2065438 to 2006, Ms. Fang had two more transplants. From May, 2065438 to May, 2007, Ms. Fang confirmed the activity of large follicles and realized natural pregnancy that month. In the past two years, 23 patients have participated in this clinical study. Follow-up showed that follicular activity was dominant in 9 patients, 2 patients got clinical pregnancy, and 2 patients got transplantable embryos, and were preparing endometrium for transplantation.