2 Overview Baizhi Bawei Pill is the prescription name, that is, Ziyin Bawei Pill in Volume III of Medical Prescription Examination [1][2]. Formerly known as Liuwei Dihuang Pill plus Rhizoma Anemarrhenae and Huangbaifang [1]. It is also called Baizhi Dihuang Pill (the first volume of pulse treatment) [1].
The main components of Baizhi Dihuang Pill are Anemarrhena asphodeloides, Cortex Phellodendri, Radix Rehmanniae Preparata, Cornus officinalis (processed), Cortex Moutan, Poria, Alismatis Rhizoma and Rhizoma Dioscoreae [3]. Has the effects of nourishing yin and reducing fire. Can be used for treating yin deficiency and excessive fire, hot flashes and night sweats, dry mouth and sore throat, tinnitus and nocturnal emission, and short and red urine.
The drug standards of the Ministry of Health of the People's Republic of China include the standards issued by the Ministry of White Dihuang Pills.
People's Republic of China (PRC) Pharmacopoeia (version 20 10) records the pharmacopoeia standards of Baizhi Dihuang Pills and Baizhi Dihuang Pills (concentrated pills).
3 Another name of Baizhi Bawei Pill is Liuwei Dihuang Pill plus Anemarrhena asphodeloides (original name)
Baizhi Bawei Pill
Ziyin Bawei Pill
4. Rhizoma Dioscoreae, Fructus Corni, Cortex Moutan, Poria, Rhizoma Alismatis, Cortex Phellodendri (parched with salt water), Rhizoma Anemarrhenae (parched with salt water), and Radix Rehmanniae Preparata [1].
Usage and dosage of white Bawei pills are fine powder, refined honey is pills, and Chinese parasol is big. Every time 100 capsules, take it with boiled water or light salt water soup on an empty stomach or before noon [1].
6 Efficacy and Indications of Baizhi Bawei Pill Baizhi Dihuang Pill has the effect of nourishing yin and reducing fire. Treating kidney fatigue, low back weakness, dysuria, wet sore of bladder, urgency of lower abdomen and Huang Chi; And bone steaming hot flashes caused by yin deficiency and excessive fire [1].
7 Source Pulse Diagnosis Volume 1
Medical Prescription Examination Volume III
8 Baizhi Dihuang Pills 8. 1 Pharmacopoeia standard is called Baizhi Dihuang Pills.
White rehmannia pill
8.2 Prescription: Rhizoma Anemarrhenae 40g, Cortex Phellodendri 40g, Radix Rehmanniae Preparata 160g, Fructus Corni 80g, Cortex Moutan 60g, Rhizoma Dioscoreae 80g, Poria 60g and Rhizoma Alismatis 60g.
8.3 Prepare the above eight medicines, pulverize them into fine powder, sieve them and mix them evenly. Adding water into 35-50g refined honey per100g powder, drying, and making into water pills; Or adding refined honey 80- 1 10g to make small honey pills or big honey pills.
8.4 Characteristics This product is a dark brown honey pill, a dark brown small honey pill or a big honey pill; It tastes sweet and bitter.
8.5 Identification (1) Take this product and observe it under the microscope: the starch granules are triangular, oval or oblong, with a diameter of 24 ~ 40μ m, and the umbilical point is short slit or herringbone (yam). Irregular branched mass is colorless and soluble in chloral hydrate test solution; The mycelium is colorless or light brown, with a diameter of 4 ~ 6 microns (Poria cocos). The parenchyma is grayish brown to dark brown, and the cells are mostly shriveled, containing brown nuclei (Radix Rehmanniae Preparata). The needle-like crystals of calcium oxalate are in bundles or scattered, and the length is 26 ~ 1 10μ m (Anemarrhena asphodeloides). Calcium oxalate cluster crystals exist in colorless parenchyma cells, and sometimes several are arranged in rows (peony bark). The epidermal cells of pericarp are orange-yellow, with polygonal surface and beaded thickening of vertical wall (Cornus officinalis). Thin-walled cells are round with oval pits and integrated pits; The vertical peripheral wall of the cells in the endodermis is wavy, thick and lignified, with sparse holes and grooves (Alisma orientalis). The fiber bundle is bright yellow, and the surrounding cells contain calcium oxalate crystals, forming crystalline fibers, and the cell walls of crystalline cells are lignified and thickened (Berberis amurensis).
(2) Take 6g of this honey pill and grind it into powder; Or take 9g small honey pills or big honey pills and cut them into pieces. Add ether 15ml, shake 1 5min, stand1hr, filter, volatilize ether from the filtrate, and add acetone 1ml to dissolve the residue as the test solution. In addition, acetone was added to paeonol reference substance to prepare a solution containing 1mg per 1ml as reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I, 20 10), respectively absorb the above two solutions 10μl, spot them on the same silica gel G thin-layer plate to make strips, use cyclohexane-ethyl acetate (3: 1) as the developing agent, unfold, take them out, dry them, and spray them with 5% acidity of hydrochloric acid. In the chromatogram of the test sample, the same blue-brown stripes appear in the position corresponding to the chromatogram of the control sample.
(3) Take 2g of this product, chop it up, add methanol Sml, heat and reflux for 65438 05min, filter, take the filtrate, add methanol to 5ml, and use it as the test solution. Another 0.65438 0 g of Astragalus membranaceus was taken, and the control medicinal solution was prepared by the same method. Then take berberine hydrochloride reference substance, add methanol to make a solution containing 0.5mg per kloc-0/ml as reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I, 20 10), absorb each 1μl of the above three solutions, spot them on the same silica gel G thin-layer plate, and use benzene-isopropanol-ethyl acetate-methanol-concentrated ammonia water (12: 3: 6: 3:/kloc-0) In the chromatogram of the test sample, the same yellow fluorescent spots appear in the positions corresponding to the chromatograms of the reference medicinal materials and the reference substance.
8.6 The inspection shall comply with the relevant provisions under Pills (Appendix 1A of Pharmacopoeia 20 10).
8.7 Determination of Content 8.7. 1 Cornus officinalis was determined by high performance liquid chromatography (Appendix VI D of Pharmacopoeia I, 20 10).
8.7. 1. 1 chromatographic conditions and system applicability test, with octadecylsilane bonded silica gel as filler; The mobile phase is tetrahydrofuran-methanol-acetonitrile -0.05% phosphoric acid solution (1: 4: 8: 87). Column temperature 40℃; The detection wavelength is 236 nm. According to the peak of loganin, the theoretical plate number should not be less than 4000.
8.7. 1.2 Preparation of reference substance solution Take a proper amount of loganin reference substance, weigh it accurately, and add 50% methanol to make a solution containing 40μg per 1ml.
8.7. 1.3 Preparation of test solution Take this product as a honey pill, grind it, take 0.7g, and weigh it accurately; Or take small honey pills or big honey pills with poor weight, chop them up, mix them evenly, take about 1g, and weigh them accurately. Put it in a conical flask with a stopper, accurately add 25ml of 50% methanol, plug it, weigh it, perform ultrasonic treatment (power 250W, frequency 33 kHz) for 65438 0 minutes, heat and reflux it for 65438 0 hours, let it cool, weigh it again, make up the lost weight with 50% methanol, shake it evenly, filter it, and accurately measure the continuous filtrate. Inner diameter 65438±0cm), eluting with 50 ml of 40% methanol, collecting effluent and eluent, evaporating to dryness, dissolving the residue with 50% methanol, transferring to a 5 ml volumetric flask, adding 50% methanol to scale, shaking, filtering, and collecting filtrate.
8.7. 1.4 Determination Method Accurately suck 10μl of control solution and test solution respectively, inject them into a liquid chromatograph, and measure them, thus obtaining the product.
This product contains Cornus officinalis, calculated by loganin (C 17H26O 10), and the honey pill shall not be less than 0.53mg per kloc-0/g, and the millet pill shall not be less than 0.40mg per kloc-0/g; Damivan shall not be less than 3.6 mg per pill.
8.7.2 Cortex Moutan was determined by high performance liquid chromatography (Appendix ⅵ D of Pharmacopoeia I, 20 10).
8.7.2. 1 chromatographic conditions and system applicability test: octadecylsilane bonded silica gel is used as filler; Using methanol-water (70∶30) as mobile phase; The detection wavelength is 274 nm. The theoretical plate number should be not less than 3500 calculated by paeonol peak.
Preparation of 8.7.2.2 Reference Solution Take appropriate amount of paeonol reference substance, weigh it accurately, and add methanol to make a solution containing 15μg per 1ml.
Preparation of 8.7.2.3 test solution Take this honey pill, grind it fine, take 0.4g, and weigh it accurately; Or take small honey pills or big honey pills with poor weight, chop them up, mix them evenly, take 0.5g, and weigh them accurately. Put it into a conical flask with a stopper, add 50 ml of 50% methanol, plug it tightly, weigh it, perform ultrasonic treatment (power 250W, frequency 33 kHz) for 45 minutes, let it cool, weigh it again, make up the lost weight with 50% methanol, shake it evenly, filter it, and take the filtrate.
8.7.2.4 method accurately absorbed 65438 00μ l control solution and 20μl test solution respectively, and injected them into liquid chromatograph for determination.
This product contains paeonol (C9H 10O3), and the honey pill shall not be less than 0.80mgper1g; Xiaomi pill shall not be less than 0.55 mg per1g; Damivan should not be less than 5.0 mg per pill.
8.8 Functional indications: nourishing yin and reducing fire. Can be used for treating yin deficiency and excessive fire, hot flashes and night sweats, dry mouth and sore throat, tinnitus and nocturnal emission, and short and red urine.
8.9 Oral administration and dosage. Shuimi pill 6g once, Xiaomi pill 9g once, Damei pill 1 pill once, twice a day.
8. 10 honey pill? Each pill weighs 9 grams.
8. 1 1 storage seal.
8. 12 Edition People's Republic of China (PRC) Pharmacopoeia 20 10 Edition
9 White Dihuang Pills (Concentrated Pills) Pharmacopoeia Standard 9. 1 Known as White Dihuang Pills (Concentrated Pills)
White rehmannia pill
9.2 Prescription: Rhizoma Anemarrhenae 25.9g, Cortex Phellodendri 25.9g, Radix Rehmanniae Preparata103.4g, Fructus Corni (prepared) 51.7g, Cortex Moutan 38.8g, Rhizoma Dioscoreae 51.7g, Poria 38.8g and Alismatis Rhizoma 38.8g..
9.3 To prepare the above eight medicines, take Chinese yam, Cortex Moutan 13g and Cornus officinalis 2 1g and pulverize them into fine powder for later use; Pulverizing Alisma orientale, Poria cocos, Anemarrhena asphodeloides and Cortex Phellodendri into coarse powder, decocting in water twice, the first time for 3 hours and the second time for 2 hours, combining decoctions, filtering, and concentrating the filtrate into fluid extract with relative density of 1.35 ~ 1.40 (20℃); Decoct Radix Rehmanniae Preparata in water for three times, the first time is 3 hours, the second time is 2 hours, and the third time is 65438 0 hours, combine decoctions, filter, and concentrate the filtrate to a fluid extract with a relative density of 65438 0.35-65438 0.40 (20℃); Soak the remaining Cortex Moutan and Fructus Corni in 70% ethanol for 24 hours, percolate, collect percolate, recover ethanol, and concentrate to a fluid extract with a relative density of 1.35 ~ 1.40 (20℃); Mixing the above fluid extract, powder and appropriate amount of starch, making into 1000 pill, drying, and polishing.
9.4 Characteristics This product is a dark brown concentrated pill; Slight gas, bitter and sour.
9.5 Identification (1) Take this product and observe it under the microscope: there are calcium oxalate clusters in colorless parenchyma cells, sometimes several of which are arranged in rows (peony bark). Starch granules are triangular, oval or oblong, with a diameter of 24 ~ 40μ m, short umbilical fissure or herringbone (yam). The epidermal cells of pericarp are orange-yellow, the surface is polygonal, and the vertical wall is thickened like beads (Cornus officinalis).
(2) Take 6g of this product, grind it, add 65438±05ml of ether, shake it evenly for 65438±05min, let it stand for 65438±0h, filter, volatilize ether from the filtrate, and dissolve the residue with 65438±0ml of acetone as the test solution. In addition, acetone was added to paeonol reference substance to prepare a solution containing 1mg per 1ml as reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I, 20 10), absorb 5 ~ 10μ l of the above two solutions, respectively spot them on the same silica gel G thin-layer plate, develop with cyclohexane-ethyl acetate (3: 1) as the developing agent, take them out, dry them, and spray them with 5% ferric chloride ethanol acidified by hydrochloric acid. In the chromatogram of the test sample, the same blue-brown spots appear in the position corresponding to the chromatogram of the control sample.
(3) Take 2g of this product, grind it, add 5ml of methanol, heat and reflux it for 65438±05min, filter it, and add 5ml of methanol to the filtrate as the test solution. In addition, 0. 1g phellodendron amurense was taken as the control medicinal material, and the control medicinal material solution was prepared by the same method. Then take berberine hydrochloride reference substance, add methanol to make a solution containing 0.5mg per kloc-0/ml as reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), each of the above three solutions 1μl was absorbed and spotted on the same silica gel G thin-layer plate, and developed into xylene-isopropanol-ethyl acetate-methanol-water (12: 3: 6: 3:/kloc-0). In the chromatogram of the test sample, the same yellow fluorescent spots appear in the positions corresponding to the chromatograms of the reference medicinal materials and the reference substance.
(4) Take 65,438 00 g of this product, crush it, add 65438±000ml of water, heat it to make it fully dissolve, heat it to boil, let it cool, filter it, take the filtrate, extract it with ethyl acetate twice, 30ml each time, combine the ethyl acetate solutions, evaporate it to dryness, and add 65438±0ml of methanol to the residue to make it dissolve, as the test solution. In addition, 4g of Radix Rehmanniae Preparata was taken as a reference medicinal material, and 60ml of water was added, and then decocted for 30min, cooled and filtered. The filtrate was extracted with ethyl acetate twice, 20ml each time, and the ethyl acetate solutions were combined and evaporated to dryness. The residue was dissolved with 1ml methanol as a reference medicinal material solution. According to the test of thin-layer chromatography (appendix ⅵ b of Pharmacopoeia I, 20 10), absorb 3 ~ 5 μ l of the above two solutions, respectively spot them on the same silica gel G thin-layer plate, and use xylene-ethyl acetate (1: 1) as the developing agent, unfold, take out, dry and spray with 2,4 dinitrophenylhydrazine. In the chromatogram of the test sample, the spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials.
9.6 The inspection shall comply with the relevant provisions under Pills (Appendix 1A of Pharmacopoeia 20 10).
9.7 Determination of Content 9.7. 1 Cornus officinalis was determined by high performance liquid chromatography (Appendix VI D of Pharmacopoeia I, 20 10).
9.7. 1. 1 chromatographic conditions and system applicability test, with octadecylsilane bonded silica gel as filler; The mobile phase is tetrahydrofuran-methanol-acetonitrile -0.05% phosphoric acid solution (1: 4: 8: 87). Column temperature 40℃; The detection wavelength is 236 nm. According to the peak of loganin, the theoretical plate number should not be less than 4000.
9.7. 1.2 Preparation of reference substance solution Take a proper amount of loganin reference substance, weigh it accurately, and add 50% methanol to make a solution containing 20μg per 1ml.
9.7. 1.3 Preparation of test solution Take an appropriate amount of this product, grind it, weigh about 0.4g, weigh it accurately, put it in a conical flask with a stopper, add 50ml of 50% methanol accurately, plug it, weigh it, heat it to 65438±0h, let it cool, weigh it again, make up the weight loss with 50% methanol, and shake it evenly. Accurately measure 10ml continuous filtrate, add it to neutral alumina column (100 ~ 200 mesh, 4g, inner diameter 1cm), elute with 50ml of 40% methanol, collect effluent and eluent, evaporate to dryness, add appropriate amount of 50% methanol to dissolve the residue, and transfer to/kloc-.
9.7. 1.4 Determination Method Accurately suck 10μl of control solution and test solution respectively, inject them into a liquid chromatograph, and measure them.
Every 1g of this product contains loganin (C 17H26O 10), and the content of Cornus officinalis shall not be less than 1.0mg.
9.7.2 Cortex Moutan was determined by high performance liquid chromatography (Appendix ⅵ D of Pharmacopoeia I, 20 10).
9.7.2. 1 chromatographic conditions and system applicability test: octadecylsilane bonded silica gel is used as filler; Using methanol-water (70∶30) as mobile phase; The detection wavelength is 274 nm. The theoretical plate number should be not less than 3500 calculated by paeonol peak.
Preparation of 9.7.2.2 Reference Solution Take appropriate amount of paeonol reference substance, weigh it accurately, and add methanol to make a solution containing 20μg per kloc-0/ml.
Preparation of 9.7.2.3 test solution Take an appropriate amount of this product, grind it, weigh about 0.4g, weigh it accurately, put it in a conical flask with a stopper, add 50ml of 50% methanol accurately, plug it, weigh it, perform ultrasonic treatment (power 250W, frequency 33 kHz) for 30 min, let it cool, weigh it again, make up the weight loss with 50% methanol, shake it evenly, and filter it. Determination? Accurately suck 65438 00μ l control solution and test solution respectively, inject them into liquid chromatograph and determine.
This product contains paeonol (c9h1OO3) per 1g, and shall not be less than 1.5mg.
9.8 Functional indications: nourishing yin and reducing fire. Can be used for treating yin deficiency and excessive fire, hot flashes and night sweats, dry mouth and sore throat, tinnitus and nocturnal emission, and short and red urine.
9.9 Oral administration and dosage. Eight tablets at a time, three times a day.
9. 10 specification 10 pill weight1.7g.
9. 1 1 storage seal.
9. 12 Edition People's Republic of China (PRC) Pharmacopoeia 20 10 Edition
10 standard of Chinese medicine department of Baizhi Dihuang pills 10. 1 concentrated pills.
10.2 white pinyin name? Rehmannia? pale
10.3 standard number WS3B 135793
10.4 prescription Anemarrhena asphodeloides 40g
Rehmannia glutinosa160g
Cortex Phellodendri 40g
Cornus officinalis? 80 grams
Yam 80g
Peony bark? 60 grams
Poria cocos 60g
Alisma orientale 60g
10.5. Pulverize Alisma orientalis, Poria cocos, Anemarrhena asphodeloides and Cortex Phellodendri into coarse powder, add water and decoct for two times, the first time is 3 hours, the second time is 2 hours, the decoctions are combined, filtered, and the filtrate is concentrated to a clear paste with a relative density of 1.30 ~ 1.35 (20℃); The slices of Radix Rehmanniae Preparata are decocted in water for three times, the first time is 3 hours, the second time is 2 hours, and the third time is 1 hour. Combining decoctions, filtering, and concentrating the filtrate to a fluid extract with a relative density of 1.30 ~ 1.35 (20℃); Take peony bark? 40g，46。 9g of Cornus officinalis, according to the percolation method under fluid extract and extract (Appendix 65438+ page 07), with &; 0% ethanol as solvent, soaking for 24 hours, percolating, collecting percolate, recovering ethanol, and concentrating to extract with relative density of 1.30 ~ 1.35 (20℃); Pulverizing Rhizoma Dioscoreae, the remaining Fructus Corni and the remaining Cortex Moutan into fine powder, mixing with the above fluid extract, making pills, drying, and polishing.
10.6 characteristics this product is a dark brown concentrated pill; Slight gas, bitter and sour.
10.7 This product was identified and observed under microscope: there were calcium oxalate clusters in colorless parenchyma cells, sometimes several of which were arranged in rows. There are needle-like crystal bundles of calcium oxalate in mucus cells, which are 80 ~ 240 μ m long. The epidermal cells of the pericarp with needle-like crystals 2 ~ 8 microns in diameter are orange-yellow, with polygonal surface and beaded longitudinal walls.
10.8 The inspection shall comply with the relevant regulations of Pills (Appendix 8).
10.9 Functions and indications of nourishing yin and reducing fire. It can be used for treating yin deficiency and excessive fire, hot flashes and night sweats, sore throat, tinnitus and nocturnal emission, and short and red urine.
10. 10 Usage and dosage: Take 8 capsules orally, three times a day.
10. 1 1 specifications Every 8 pills is equivalent to 3g of the original crude drug.
10. 12 storage seal? .
1 1 description of Baizhi Dihuang pill 1 1. 1 drug name Baizhi Dihuang pill
1 1.2 pharmaceutical hanyu pinyin baizhi Dihuang pill
1 1.3 honey pills, each weighing 9g; Concentrated pills per 10 grain weight1.7g.
1 1.4 white Dihuang pills are brown honey pills, dark brown small honey pills or big honey pills; It tastes sweet and bitter.
1 1.5 The main components of Baizhi Dihuang Pill are Rhizoma Anemarrhenae, Cortex Phellodendri, Radix Rehmanniae Preparata, Fructus Corni (processed), Cortex Moutan, Rhizoma Dioscoreae, Poria and Alismatis Rhizoma.
1 1.6 Pharmacological effects of Baizhi Dihuang Pills 1. Hypoglycemia. Taking Dihuang Pill 2.5g/kg and 5.0g/kg in mice can reduce the blood sugar of normal mice and alloxan diabetic mice, and reduce the daily water consumption of mice.
2. Clinical report: ① Sexual dysfunction: 47 patients with nocturnal emission, aged 65,438 08 ~ 38 years, were treated with Baizhi Dihuang Pill, which were divided into yin deficiency with excessive fire, damp-heat downward flow and kidney deficiency with unconsciousness. 36 cases (76.5%) were cured and 7 cases (65,438 0.5%) were improved by decocting twice. ② Single benign thyroid nodule: 26 patients were treated with Baizhi Dihuang Pill or its concentrated pills, 9 grams each time, 8 pills each time, 3 times a day, and 90 days was 1 course of treatment. After 1 ~ 2 courses of treatment, 20 cases (77%) disappeared after examination and B-ultrasound exploration. Compared with before treatment, 4 cases were atrophied, accounting for 15%, and 2 cases remained unchanged, with a total effective rate of 92%. Most patients are effective after 1 course of treatment. ③ Deafness: 44 cases of deafness caused by aminoglycosides were treated with Baizhi Dihuang Pill, 2 pills/time, morning and evening 1 time, taken with warm water. 32 cases (simple tinnitus 16 cases, tinnitus with dizziness 16 cases) were cured within 2-5 days, and 65438+ cases were improved after 5- 10 days.
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1 1.7 Baizhi Dihuang Pill is mainly used for nourishing yin and reducing fire. Can be used for treating yin deficiency and excessive fire, hot flashes and night sweats, dry mouth and sore throat, tinnitus and nocturnal emission, and short and red urine.
1 1.8 Usage and dosage of Baizhi Dihuang Pill. Shuimi pill 6g once, Xiaomi pill 9g once, Damei pill 1 pill once, twice a day. Concentrated pills, 8 pills at a time, 3 times a day.
1 1.9 Note 1. Avoid indigestible food.
2. Patients with cold and fever should not take it.
3. People suffering from serious chronic diseases such as hypertension, heart disease, liver disease, diabetes and kidney disease should take it under the guidance of a doctor.
Children, pregnant women and lactating women should take it under the guidance of a doctor.
5. After taking the medicine for 4 weeks, the symptoms have not eased, so I have to go to the hospital.
6. It is forbidden for people who are allergic to Bai Dihuang Pills, and should be used with caution for those who are allergic.
7. White Dihuang Pills are prohibited when their properties change.
8. Children must use it under the supervision of adults.
9. Please put the white Dihuang pill out of the reach of children.
10. If you are using other drugs, please consult a doctor or pharmacist before using Baizhi Dihuang Pills.
1 1. 10 If used with other drugs, drug interactions may occur. Please consult a doctor or pharmacist for details.
11.11expert comments1. (1) Exhaustion: Symptoms include red cheekbones, dry mouth, dreaminess, nocturnal emission, restless sleep, dizziness, fever due to five senses, scanty and hot urine, red tongue with little coating and rapid pulse. (2) Toothache: The symptoms are red cheekbones, dry mouth, hot flashes, night sweats, nocturnal emission, low back pain, red tongue and rapid pulse. (3) Bloody stranguria: the symptoms are prolonged hematuria, dark red blood, burning and astringent urine, backache, hot flashes, nocturnal emission, or fatigue, thin, dry and red tongue, and deep and thin pulse.
2. Indications for application: The key points of syndrome differentiation of Baizhi Dihuang Pill are liver and kidney yin deficiency, yin deficiency and hyperactivity of fire. The main symptoms are soreness of the waist and knees, tinnitus and deafness, night sweats, hot flashes due to bone steaming, dry cheekbones and throat, red tongue with little coating, and rapid pulse.
3. Adverse reactions: oral administration of Baizhi Dihuang Pill leads to itching, tingling, hemorrhoids, bloody stool and nasal mucosa exudation 1 case.
4. Attention when using: loose stool with spleen deficiency is not suitable for dyspepsia.
5. New clinical use: (1) Treating single benign thyroid nodule: It is reported that Baizhi Dihuang Pill is effective in treating single benign thyroid nodule. Methods: Baizhi Dihuang Pill was taken orally, 9g/ time; Or its concentrated pills, 8 capsules/time, 3 times/day, 90 days is 1 course of treatment. Results: 26 cases of thyroid solitary benign nodule were treated with Baizhi Dihuang Pill. After 1 ~ 2 courses of medication, 20 cases were cured (confirmed by surgical examination and B-ultrasound examination), 4 cases were effective (obviously less than before treatment) and 2 cases were ineffective (unchanged before and after treatment), with a total effective rate of 92%. Most patients take 1 course of medicine to produce curative effect. (2) Treatment of ototoxic symptoms caused by aminoglycosides: 44 patients with ototoxic symptoms caused by aminoglycosides were treated with Baizhi Dihuang Pill, which achieved remarkable results. Methods: Take Baizhi Dihuang Pill orally, 2 pills/time, 1 time, and take it in warm water every morning and evening. Results: Among the 44 patients, 32 patients were cured after 2-5 days (including simple tinnitus 16 cases and tinnitus with dizziness 16 cases). After 5 ~ 10 days, there were 10 cases of improvement (including 8 cases of tinnitus with vertigo and 2 cases of tinnitus with hearing loss); After taking the medicine for more than 15 days, 2 cases were ineffective (there was no obvious change before and after treatment). The total effective rate is 95%. (3) Treatment of nocturnal emission: 36 cases of nocturnal emission due to kidney deficiency were treated with Baizhi Dihuang Pill. After 3-5 courses of medication, 29 cases were cured, 5 cases were improved and 2 cases were ineffective, with a total effective rate of 94.5. Methods: Take Baizhi Dihuang Pill orally, 2 pills/time, 1 time, in the morning, in the middle and in the evening, and take it with warm water. During treatment, people should avoid spicy food and overwork. The 20th is 1 course. (4) Treatment of male infertility: 55 cases of male infertility due to yin deficiency and excessive fire were treated with Baizhi Dihuang Pill. After 4 ~ 6 courses of medication, 48 cases were cured and 7 cases were ineffective. Methods: Take Baizhi Dihuang Pill orally, 2 pills/time, 1 time, and take it in warm water every morning and evening. 30 days is 1 course of treatment. Generally, taking 1 ~ 2 courses can take effect. During taking the medicine, it is advisable to abstain from sexual intercourse. (5) Treatment of non-* * syndrome: 12 The patients with non-* * syndrome of yin deficiency and excessive fire were treated with Baizhi Dihuang Pill. After 3-5 courses of medication, 9 cases were cured and 3 cases were ineffective. The cure rate is 75%. Methods: White Dihuang Pills were taken orally, 2 pills/time, 3 times/day, with warm water. The 20th is 1 course. (6) Treatment of senile xerosis: Some people used Baizhi Dihuang Pill to treat senile xerosis 19 cases (dry mouth, dry nose and dry stool). After 10 ~ 15 days, 16 cases were cured, 2 cases were improved, and 1 case was ineffective. The total effective rate is. Methods: Baizhi Dihuang Pills were taken orally, 2 pills/time, 65438 0 times, with warm water in the morning, middle and evening respectively. It usually takes 3 to 5 days to take effect. (7) Treatment of diabetes: 265,438+0 cases of diabetes with yin deficiency and excessive fire were treated with Baizhi Dihuang Pill. After 3-5 courses of medication, 17 cases were cured, 3 cases were improved and 1 case was ineffective. The total effective rate is 95%. Methods: White Dihuang Pills were taken orally, 2 pills each time, 65438 0 times in the morning and evening, and taken with warm water. 30 days is 1 course of treatment, and taking medicine 10 ~ 15 days can get obvious effect. (8) Treatment of nephrotic syndrome: The disease is a clinical syndrome caused by various reasons, and its clinical manifestations are massive proteinuria, hypoproteinemia, hyperlipidemia and edema of different degrees. Nephrotic syndrome belongs to the category of edema, virtual tuberculosis and low back pain in traditional Chinese medicine. Some people use Baizhi Dihuang Pill to treat patients with nephrotic syndrome, and the effect is quite good. Usage: Take Baizhi Dihuang Pills orally, 2 pills/time, 3 times/day, with warm water. 15 days is 1 course of treatment. Efficacy: Baizhi Dihuang Pill is used to treat 65,438+06 cases of nephrotic syndrome. After 2-4 courses of medication, 13 cases were cured, 2 cases were improved, and 1 case was ineffective. The total effective rate is 94%. General drugs take effect after 1 week. Treatment of Cemtc(9) acute urinary tract infection: 22 patients with acute urinary tract infection were treated with Baizhi Dihuang Pill. 6 ~ 12 days, 18 cases were cured, 2 cases were improved and 2 cases were ineffective. The total effective rate was 9 1%. Usage: Take Baizhi Dihuang Pills orally, 2 pills/time, 3 times/day, with warm water. (10) Treatment of intractable night sweats: Modern medicine believes that this disease is caused by autonomic nerve dysfunction. Traditional Chinese medicine says that intractable night sweats are caused by lung qi deficiency, disharmony between camp and health, yin deficiency and excessive fire. Therefore, it is effective to treat with Baizhi Dihuang Pill. Usage: Take Baizhi Dihuang Pills orally, 2 pills each time, morning and evening 1 time, 1 day1time. Results: Baizhi Dihuang Pill treated 5 cases of intractable night sweats/KLOC-0. After 2 ~ 3 courses of medication, 2 cases were cured 1 case, 2 cases were improved, and1case was ineffective. The total effective rate is 93%. (1 1) Treatment of recurrent hemospermia: It is reported that 30 patients with recurrent hemospermia were treated with Baizhi Dihuang Pill, 1 course of treatment for 7 days, generally taking medicine for 2-3 courses. Results: Among 30 cases, 1 1 case was cured (clinical symptoms disappeared, * * *, prostatic fluid was normal, and there was no recurrence after half a year's follow-up); Effective (clinical symptoms disappeared, * * *, prostatic fluid was normal, but recurred after 2 ~ 3 months) 13 cases; 6 cases were ineffective (no obvious improvement in clinical symptoms and prostate fluid test). During treatment, avoid alcohol and spicy products, and be careful about sexual intercourse. (12) Treatment of climacteric syndrome: It is reported that Baizhi Dihuang Pill (decoction) is used to treat climacteric syndrome. Radix Curcumae, Radix Bupleuri, and Rhizoma Chuanxiong are added for those who are upset and irritable; If palpitation and insomnia is uneasy, add Semen Ziziphi Spinosae, Cortex Albizziae, Os Draconis preparata and Concha Ostreae preparata; For dizziness, soreness of waist and knees, and fever of hands and feet, turtle shell, Lycium barbarum, Achyranthes bidentata and Cortex Lycii are added. Half a month is 1 course of treatment. Results: Among 80 patients, 56 cases were clinically cured, 265 cases were improved and 438 cases were ineffective. The total effective rate is 96%.
1 1. 12 Remarks