Can CML be cured? Can it survive for a long time?

The way to cure or completely eliminate CML stem cells is bone marrow transplantation.

However, it must be noted that the conventional treatment of CML is not transplantation, but taking tyrosine kinase inhibitors (including the first and second generation targeted drugs, the third generation has been clinically tested in China, and it will take some time). Because the transplant operation is very demanding, and once it fails or has postoperative complications, the patient's life will be in danger. At present, on a global scale, patients with CML still choose to take medicine for treatment.

So can you cure it by taking medicine? We must first discuss what is "cure". At present, no drug can be proved to cure chronic myeloid leukemia. From this perspective, "there is no cure."

However, there are also some patients with very good curative effect who can be considered as "cured" if they stop taking drugs or do not need further treatment.

A series of problems such as when to stop taking drugs and whether it is possible to relapse are still being explored, and the specific implementation is also very complicated. The patient still has to go to a big hospital, so please ask an experienced doctor to make a judgment.

To put it simply, the withdrawal criteria are: drug abuse for more than 3-5 years, negative 1-2 years of high sensitivity gene test, and no history of acceleration or mutation. Note that meeting the withdrawal criteria does not mean that you can stop taking drugs. Less than half of your patients can stop taking drugs. Because the standard of stopping drugs in clinic is not uniform, the first-generation drugs taken by everyone are different from the second-generation drugs, so the doctor has the final say.

If you don't meet the withdrawal criteria, you will almost relapse if you stop taking the drug yourself.

According to the latest clinical data in the United States, the 5-year survival rate of patients with CML is about 90%, which is the same as that of the general population, which means that most patients with CML can survive for a long time.

I wish all patients well.

Wechat official account: Idol.