What about myasthenia gravis?

Symptoms: The typical clinical feature of myasthenia gravis is fatigue and weakness after skeletal muscle activity, and eye involvement is the most common, which can be relieved by rest or cholinesterase inhibitors. Typical symptoms include: drooping eyelids in one or both eyes, strabismus or diplopia, dysphonia, dysphagia, chewing difficulty, facial expression loss, proximal limb weakness (such as inability to lift shoulders and hands), shortness of breath and cough weakness.

Children's myasthenia gravis can generally be divided into three types, and each type has its own different manifestations.

1. neonatal transient myasthenia gravis: it is neonatal transient myasthenia gravis, and most of its mothers suffer from myasthenia gravis. Muscle weakness occurs within a few hours to three days after birth, which can be manifested as low crying, decreased sucking ability, difficulty swallowing and breathing, facial muscle weakness, and decreased active exercise. Half of the children have generalized dystonia, usually without ophthalmoplegia.

Most of these children's symptoms are not obvious, and some can relieve themselves. The duration is generally less than 5 weeks, and the condition can be alleviated after half a month. But severe cases can also die of respiratory failure.

2. Congenital myasthenia gravis: This type is related to heredity, but the mother does not necessarily have myasthenia gravis. Most children have weak fetal movement, which is characterized by symmetry and persistence after birth, incomplete extraocular muscle weakness and ptosis. The main manifestations of neonatal period are low crying and feeding difficulties. The course of disease is generally long, and a few children can relieve themselves.

3. Juvenile myasthenia gravis: This type is the most common, mostly caused by acquired pathogenic factors. Most children get sick before the age of 10. The onset can be insidious or acute, and is often induced by acute fever. It is divided into eye muscle type, whole body type and brain stem type.

The symptoms of different children vary greatly, some may only be local weakness of eye muscles, and some may affect the whole body muscles. When a muscle group is used frequently, the symptoms will be aggravated, which can be relieved after a period of rest, and will be aggravated after being used again, and so on. However, most children's symptoms will become more and more serious over time, usually reaching a very serious level within a few years of onset.

This disease is similar to many diseases and needs to be identified. For example, acute myasthenia needs to be differentiated from periodic paralysis, myelitis and acute inflammatory demyelinating polyradiculopathy; Chronic myasthenia gravis should be differentiated from oculomotor nerve paralysis, polymyositis, progressive muscular dystrophy, mitochondrial myopathy, glycogen storage disease, cancerous myasthenia gravis and motor neuron disease.