Repetitive transcranial magnetic stimulation is a safe, noninvasive and painless new cognitive neuroscience technology. It uses time-varying magnetic field to induce current in the cerebral cortex, and affects brain metabolism and electrical activity of nerve tissue by changing the action potential of neurons in the cerebral cortex, and then affects the stimulation area and related areas. High-frequency (>: 5Hz)rTMS can promote the excitability of cerebral cortex, while low-frequency (≤ 1Hz)rTMS can inhibit the excitability of cerebral cortex, which has been widely used in clinical diagnosis and treatment of psychiatry and neurology. Low frequency (≤ 1Hz)rTMS can inhibit the excitability of cerebral cortex and promote the release of γ -aminobutyric acid (GABA) and 5-HT. GABA is an important inhibitory neurotransmitter in mammalian central nervous system.
There are several reasons why Naoyukang transcranial magnetic stimulation rTMS promotes cognitive function: firstly, rTMS can prolong the time of neuron depolarization, enhance the transmission speed of electrical signals between neurons and change the electrical activity of neurons; Second, rTMS can increase the expression of brain-derived neurotrophic factor (BDNF)mRNA and change the translation level of protein, thus achieving neuroprotective effect; Third, rTMS can adjust the function of cerebral cortex by changing the excitability of cerebral cortex and enhancing synaptic plasticity.