Digoxin is a commonly used cardiotonic drug in clinic. The safe range of effective treatment of this drug is narrow, the therapeutic dose is very close to the toxic dose, and the individual difference is also great. If taken improperly, it is prone to toxic reactions, such as anorexia, nausea, vomiting and diarrhea. Visual impairment, such as yellow vision, green vision, blurred vision, photophobia, etc. ;
Symptoms of nervous system, such as dizziness, headache, insomnia, delirium, insanity, etc. The cardiac reaction is characterized by various arrhythmias that are difficult to distinguish from the symptoms of heart disease itself, such as ventricular premature beats, paroxysmal supraventricular and ventricular tachycardia, atrial fibrillation and different degrees of atrioventricular block. In particular, elderly patients with heart failure are more prone to poisoning symptoms.
Extended data:
Digoxin (isohydroxydigitalis glycoside) is an intermediate cardiac glycoside, whose main function is to increase myocardial contractility, slow down heart rate and inhibit cardiac conduction.
Digoxin is an intermediate cardiac glycoside, which is white crystal or crystalline powder. Tasteless; It tastes bitter. In the treatment, the effect on the heart is a positive inotropic effect, which slows down the heart rate and inhibits heart conduction. It is suitable for congestive heart failure with low cardiac output, atrial fibrillation, atrial flutter and paroxysmal supraventricular tachycardia.
Among digitalis drugs, digoxin is excreted faster, accumulated less, and absorbed incompletely and irregularly by oral administration. The blood concentration of human poisoning is 2.73 ~ 3.9 nmol/L, and the lethal dose of adults is 10mg.
Baidu Encyclopedia-Digoxin