Guo Jing's name was given by Qiu Chuji. At that time, one of the Guo and Yang families was named Guo Jing and the other was named Yang Kang, which means not losing the shame of Jingkang.
Yang Guo's name was given by Guo Jing, hoping that he could change his father (Yang Kang)'s mistakes.
The name Yuan Chengzhi can be regarded as inheriting the ambition of his father (Yuan Chonghuan).
Zhang Wuji was named because he worshiped Xie Xun as his adoptive father and adopted the name of Xie Xun’s biological son (Xie Wuji).
The other protagonists’ names are not stated to have any special meaning in the book.