〖APTX4869〗 is the name of the poison that appeared in "Detective Conan". The protagonist Shinichi Kudo became smaller because he was forced to take it. After becoming smaller, he changed his name to Edogawa Conan. The poison's name was not revealed when it was first introduced. Shirley (Haihara Ai) was ordered by the organization to develop an unknown poison. Because APTX4869 was used by the organization during the experimental stage and the real reason why her sister was killed, the development and research was interrupted. She was imprisoned by the organization and became smaller after taking APTX4869. , it is now confirmed that two people have become smaller due to APTX4869: Edogawa Conan (Kudo Shinichi) and Haihara Ai (Miyano Shiho, codename Shirley).
[Edit this paragraph]〖Pharmacological Research Report〗
"APOTOXIN" is a combination of Apoptosis (programmed cell death) and TOXIN (toxin). It is a drug that unconditionally promotes the self-destruction of human cells. The details are unknown.
The concept of Apoptosis (cell suicide) is not very old. Traditionally, cell death is considered to be "cell necrosis", while self-death is just a form of necrosis. Cell necrosis is a word indicating the death of cells due to some external factors. For example, cuts, burns, etc., hinder cell functions, damage cell membranes, and cause internal cytoplasm, ions, etc. to be lost outside the cells. In other words, there is some kind of destructive external force that causes cells to "accidentally die", causing edema, fever, and even suppuration and bleeding. Such obvious phenomena have been known for a long time because they can be directly observed, and it has long been thought that this is how cells die.
In contrast, cell suicide is a phenomenon in which cells are automatically destroyed and absorbed by surrounding cells. For example, when a tadpole changes into a frog, its tail disappears. In the early stages of the formation of human fingers, the web-like part between the fingers disappears, and the cells in this part die to form the fingers. Or it is not the process of the metamorphosis stage or the generation stage of life, but it is the abnormal self-destruction of cells caused by radiation or drugs, excessive cell division, or the self-destruction of cells that have expired, which is the daily self-death of cells. phenomenon.
Unlike cell necrosis, which is greatly affected by surrounding cells, the phenomenon of self-death is very "smart". Careful analysis of the DNA in the nuclei of self-dead cells can confirm very small fragmentation changes, a phenomenon called "coagulation necrosis." This fragment is quickly absorbed by surrounding cells, and its postmortem form becomes nutrients for surrounding cells.
The interesting thing about cell death is that the "place" where the cell dies itself is determined. For example, in the above-mentioned case of the formation of fingers, the information that "there are cells that are not needed" is recognized around the dead cells. Although this process has not yet been explained clearly, it can be seen through the process of the cells in the webbed part disappearing and the fingers are formed. , conveying the message “don’t want those cells” through the cortex.
If the process becomes irreversible through processes such as radiation, the cells will judge that they are abnormal cells and cannot divide or proliferate. After making this judgment, the "death genetic gene" on the DNA in the cell will be activated, inducing the cell's self-death process. Dozens of "death genes" can now be analyzed, and research is underway to analyze their functions.
In summary, self-death is a phenomenon in which cells choose to die at their own discretion in order to remove excessively proliferating unnecessary cells or to cause unexpected and sudden mutation of somatic cells to threaten life. . Therefore it becomes "suicide".
Among the current research on anti-cancer drugs, drugs that cause cell suicide are being studied. "Cancer" is a disease caused by the continuous proliferation of cells that should be eliminated through self-death. Therefore, cancer can be cured by promoting the normal process of self-death. The anticancer agents currently in use are drugs that induce cancer cells to commit suicide. However, their side effects are that they also induce the suicide of normal cells.
APTX4869 is a drug that causes explosive self-destruction of body cells. The side effect is that when young people (under 20 years old) take it, there are cases where the body age returns to about 10 years younger. Is such a thing even possible?
There are limits to somatic cell division in the human body.
This value, called "HEAFLICK", is determined by the number of "TTAGGG" bases attached to the end of the DNA. Beyond this value, cells will no longer be able to divide and proliferate.
If APTX4869 is a drug that applies the above principles and promotes changes in bases, it should be possible to produce side effects such as "shrinking".
There is an interesting report of a "c-myc" gene reported as a cancer-related gene - this gene promotes cell proliferation, thus activating this gene Removing the remaining cells from the factor of proliferation is tantamount to inducing cell suicide. In other words, the process of "c-myc" promoting production is opposite to the process of cell death.
The process of APTX4869 is speculated to be: cells that are judged by their base to age and die are activated by the c-myc gene. However, after a certain degree of cell suicide, the reactivated c-myc promotes the proliferation of younger cells through base stretching - thus causing the overall rejuvenation of somatic cells, resulting in "smaller" cells. .
Of course there are still problems, and it can be said that there are quite a few.
First of all, no matter how many young cells proliferate, there will be no "rejuvenation" phenomenon. Because theoretically speaking, this cell proliferation process is the same as cancer cell proliferation. It is a disordered proliferation that will obviously produce cells that damage body functions. In the human body, corresponding command signals are needed to give the body shape and functions. It is very strange that such command signals can still be transmitted normally when cells are dying and cell proliferation is occurring in parallel. It is incredible that the cells of the body can still function normally under such instructions.
The "Detective Conan" who has the appearance of an elementary school student should have substances like cancer cells in his body?
The second is the problem of nerve cells. Nerve cells form within months of fertilization and do not divide and proliferate thereafter, so APTX4869 has no effect. But it is a fact that an average of 100,000 brain cells die every day. This is normal "cell death", that is, cells die at the end of their life span. Of course, this process is also formed through intracellular activities, and APTX4869, which unconditionally induces cell suicide, is the only exception to this process, which is quite unnatural.
In addition to nerve cells, there are other cells that are formed after fertilization and do not divide or proliferate thereafter, which are heart cells. If cardiac cells, like nerve cells, do not undergo any changes, it would be equivalent to a 7-year-old child having a 17-year-old heart, which would cause serious damage to the circulatory system. And if the heart cells and the body undergo the same changes that degenerate to the level of a 7-year-old child, there will be a problem: it is difficult to imagine that cells that have undergone such drastic changes can still be normal. I'm just afraid of severe heart failure and death. Moreover, in the TV version of "Conan", Conan and Haibara experienced unimaginable pain (mainly manifested in skeletal changes and heart acceleration) when they used drugs several times (including changing back to their original state and disappearing and returning to childhood). and violent beating reaction), it can be seen that if a complete antidote other than APTX4869 is used multiple times, the normal body will break through the physiological limit due to multiple abnormal body reactions (such as blood vessel bursting, severe damage to heart function, etc. Phenomenon), thus completely collapsing under the powerful side effects of APTX4869's programmed cell self-death interacting with other growing cells in the body and even antagonizing the reaction, which is the result of triggering final death. But this is just conjecture. At least for now, this is still a very dangerous approach. And in the comic version of "FILE.652 What I Really Want to Ask You", Haibara also said to Conan: "Your body has already produced antibodies to this medicine. If you continue to take it, the duration will become longer and longer." Short..."So, if Conan and Haibara don't find the final antidote to APTX-4869 early, I'm afraid Conan will have less and less time to use his true form in the future, and even the process of taking the real antidote will be difficult." Will be affected.
〖The Significance of Drugs〗
As a side note, the body of a 17-year-old changes into a 7-year-old body that releases intense heat, and a 7-year-old body becomes a 17-year-old body. The same fever occurs when one is older - violating the law of conservation of energy.
If there could be a drug that produced such an incredible phenomenon, just proposing the basic theory would be enough to win the Nobel Prize.
It will be an important research topic that can "spark a thousand waves with one stone" in molecular biology, which has been very popular in recent years.
APTX4869 (drug that makes Shinichi smaller) APTX means "the famous detective who never fails", 4869 is pronounced "Sherlock", Sherlock Holmes, the character written by Conan Doyle, Needing no introduction, he is the character who has been put on the screen the most in history, is also synonymous with detectives, and is Shinichi’s idol!
"4869" If you pay attention to the pronunciation of Japanese numbers, 4 = し(shi), 8 = はち(hachi), 6 = ろく(roku), 9 = く(ku), choose which one If you combine the pronunciation into katakana, you will find that it is シャーロック (Sherlock). Similar to what we say 520 (I love you). This number was the unlock password set for Conan's cell phone when Xiaolan was suspected of being Kudo Shinichi (anyone who has watched Conan will know this).
〖Drug Developer〗
Haibara Ai
Origin of the name:
"Hai" is Cordelia The "Gray" of A. Gray and the "I" of V.I. Woscowsky.
Japanese: はいばらあい (息いばらあい (偂い) in Japanese, its Roman phonetic notation is "ai", and its pronunciation is the same as the English "I".)
Roman pinyin: Haibara Ai [Ash: はい, hai; Original: ばら, bara (r is pronounced as l); Sad: あい, ai]
Original name: Miyano Shiho (Japanese-English mixed)
Roman pinyin: Miyano Shiho
Japanese: みやのしほ[宫: みやmiya; 野: のno; 志: しshi; 宝: ほho]
Codename: Shirley ( Sherry) (also translated as Sherry)
Nickname: Xiao Ai [Japanese: 爱ちゃんAi'chyan]
Age: 7 years old (actual age: 18)
< p> Comics Volume 19 FILE.190 56,000 Hostages (56,000 Hostages) TV130-131 Indiscriminate Intimidation Incident in the ArenaBirthday: December 29
< p> Constellation: CapricornIdentity: Formerly a researcher of a mysterious dark organization, and later a member of the Young Detective Corps (a woman from the dark organization in TV129, Volume 18)
Reason for shrinkage: Because the organization killed her sister Miyano Akemi, she betrayed them and stopped drug research, and was later imprisoned in a gas chamber by the organization. He originally wanted to commit suicide by eating APTX4869, but he became smaller and escaped. Comics Volume 18 TV129 The Woman from the Dark Organization
The biggest invention: APTX4869 (the drug that makes Shinichi smaller)
Height: 105CM (provided by Kudo Izumi)
< p> Weight: 18kgPersonality: Erudite and good at reasoning (not inferior to Conan, giving girls a fight). His thoughts are unpredictable and unusually calm. Her cold (Misuhiko calls her gentle...) appearance hides a mysterious charm. Vague kindness, cold innocence, and some rebellious thoughts (loving to make mischief). She has an unforgiving mouth (Conan always gives her three points). Very strong willed. It seems that he has some feelings for Shinichi (often joking with Conan), he doesn't do anything he's not sure about, and he doesn't say anything he's not sure about.
Blood type: AB
Hair: Brown (some say coffee color. Because I am a Japanese-English mixed race, my hair is naturally curly, and brown hair is also natural)
Additional Notes - M3 The Magician at the End of the Century: Deep Orange; M4 The Assassin in the Pupil: Golden Yellow; M5 Countdown to Heaven and Others: Brown
Residence: Stay after becoming smaller Next door to the new family in Lane 22, Section 2, Mihua Road, Dr. Ali's house (comic volume 18, TV129, a woman from a dark organization).
Incidentally, Shinichi's home is No. 21, Section 2, Mihua Road, while Holmes's home address is No. 221B, Baker Street. What do you think?
Hobbies: Reading women's fashion magazines; playing with Shinichi; watching football games; taking care of small animals; playing on the computer.
Specialties: Fake crying, use the computer to develop poison, and shoot jokes as a joke (raising a gun to scare Conan The posture is very cool)
First appearance:
Comics: Volume 18 of FILE.6 Transfer Student;
TV: 129 Women’s University from Dark Organization Professor Murder Case
OVA: 1 Conan vs KID vs Yaiba Battle for the Sword
Theatrical Version: M3 The Magician at the End of the Century
Common expressions: No expression, Or sneer. The most endearing thing about Haihara Ai is the smile in her indifference that seems to be when she sees what she longs for.
IQ: 200. (Just speculation) When Xiao Ai and Conan are together, the latter always steals the show, but this is limited to solving crimes. Conan is certainly shrewd, but in Japan, although there are very few people whose reasoning ability is comparable to Conan's, there are still some. However, the person who can invent this miraculous drug APTX4869 is unprecedented, if not unprecedented. If we only consider the scientific value of this medicine, Hui Yuan would have won the Nobel Prize without any effort.
〖Antidote Preparation〗
Conan obtained the antidote formula through an accidental personal experience. Please remember three prerequisites when taking this medicine. One is to have a cold and fever. Under the symptoms, the second is that you have taken APTX-4869, and the third is that if you don’t have the first two conditions, give up!
Ingredients:
One bottle of dried white powder
One box of cold medicine (preferably from Contech)
One expired quick-acting cold medicine Packet (must be expired, be careful not to use quick-acting cold medicine for children)
One pack of instant coffee (leave it open for 24 hours after opening)
Preparation method:
1. Distill the white stems and take out one-third of the distilled liquid.
2. Pour the instant coffee into the liquid and dissolve it fully.
3. Grind the cold medicine and add it. After making sure that most of it is dissolved, add the quick-acting cold medicine
4. Stir for one minute and then heat to boiling
< p> 5. Stop heating when the liquid turns into a paste, transfer to an evaporating dish and evaporate to dryness. (It must be steamed to dryness, and if it cannot be steamed dry, then put it in the sun)6. After completion, be careful not to get wet. You can seal it with a desiccant and store it
〖Conan uses the antidote Plot time〗
1. Take APTX-4869, the latest experimental antidote that lasts for 24 hours, twice in a row.
Details: Conan was invited to a village to investigate. By mistake, he had taken the cold medicine given by Dr. Ali before (it was actually the antidote to APTX-4869, newly developed by Haiyuan that lasts for 24 hours). After appearing at the murder scene and joining forces with Hattori Heiji to expose the fake Kudo Shinichi, he went to the toilet to change under Hattori's cover. As a result, Haibara Ai, who had been waiting for a long time, gave the same antidote to Conan for the second time, allowing him to There are more than 4 hours of control time for the original body.
Origin: Comic version: FILE.646 Village of Hatred ~ FILE.652 What I Really Want to Ask You TV Version: 521 Murderer-Kudo Shinichi ~ 523 What I Really Want to Ask