1. Serious adverse reactions
(1) Shock: It has been reported that similar drugs (omeprazole, lansoprazole) occasionally have allergic reactions or shock. Therefore, when there is an abnormal situation, the drug should be stopped and appropriate treatment measures should be taken.
(2) pancytopenia, thrombocytopenia and agranulocytosis: pancytopenia (unknown probability), thrombocytopenia (0. 1 ~ 5% unsatisfactory) and agranulocytosis (unknown probability) occurred. Once diagnosed, stop taking it and give appropriate treatment. In addition, similar drugs (omeprazole, lansoprazole) have also reported hemolytic anemia.
(3) Abnormal liver function: Due to abnormal liver function (0. 1 ~ 5% dissatisfaction) and jaundice (unknown probability), once diagnosed, you should stop taking it and give appropriate treatment.
2. Serious adverse reactions (foreign cases)
Visual impairment: There are reports of visual impairment caused by the use of similar drugs (omeprazole) abroad.
3. Other adverse reactions
0. 1% ~ 5%
Below 0. 1%
The incidence is unknown.
Itching sensation of rash and urticaria
Erythropenia, leukopenia, leukocytosis, eosinophilia, neutropenia, lymphopenia anemia.
Liver, aspartate aminotransferase, GPT, alkaline phosphatase, γ-GTP, lactate dehydrogenase and total bilirubin increased.
circulatory system
throb with terror
digestive system
Constipation, diarrhea, abdominal distension, nausea, lower abdominal pain and indigestion.
Mental nervous system
have a headache
Dizziness, lethargy, weakness of limbs, insensitivity, low grip strength, slurred speech, stumbling gait, lethargy and loss of discrimination.
other
Edema, elevated total cholesterol, neutral fat and urea nitrogen, proteinuria, fatigue, fever, blurred vision and dizziness.
Note 1): If such symptoms appear, you should stop taking the medicine.
Note 2): Hematological examination should be carried out regularly during medication. If any abnormality is found, the drug should be stopped and appropriate treatment measures should be taken.
Note 3): Blood biochemical tests should be carried out regularly during medication. If any abnormality is found, the drug should be stopped and appropriate treatment measures should be taken.
Note 4): Patients with liver cirrhosis have reported weakness of limbs, insensitivity, low grip strength, slurred speech, stumbling gait, delusion, lethargy and loss of discrimination. In addition, it is reported that 1 patients with liver cirrhosis with a past history of hepatic encephalopathy abroad have mental disorders and drowsiness.
taboo
Allergic to rabeprazole sodium, benzimidazole metabolites or excipients.
Matters needing attention
Patients should pay attention to observation during treatment, and the cumulative dose should be kept as low as possible.
The possibility of malignant gastric or esophageal diseases should be ruled out before rabeprazole sodium is used to treat gastric or esophageal diseases.
Patients who have been treated for a long time (especially those who have been treated for more than one year) should be monitored regularly.
Patients should note that Bo Park Jung Su tablets should not be chewed or crushed, but swallowed whole.
Patients with a history of drug allergy should use this product with caution. In addition, there are reports of adverse reactions of mental nervous system in patients with liver cirrhosis, and patients with liver function damage should be cautious in using drugs.
Medication for pregnant and lactating women
Because there is no strictly controlled clinical research and use experience of pregnant women, it can only be used when the therapeutic benefits outweigh the possible risks to the fetus. Whether rabeprazole sodium can be secreted into human milk is unknown (it has been observed in animal experiments), and there is no research on lactating women at present, so rabeprazole sodium should not be prescribed to lactating women. If rabeprazole sodium treatment is necessary, breast-feeding should be stopped.
Children's medication
Not recommended for children, inexperienced.