In the past, Taipei Rong Zong once published in the American Society of Reproductive Medicine 20 13 that curettage can increase the success rate of artificial reproductive technology by 1.6 times. The reason may be that curettage wound will attract bone marrow mesenchymal stem cells to migrate to endometrium, and the secretion products of this mesenchymal stem cells may activate embryos and improve the implantation rate.
Recently, further research by Professor Li Xinyang from Department of Gynecology of Taipei Rongzong and Professor Zhou Zushu from Department of Internal Medicine of National Taiwan University Hospital found that mesenchymal stem cells can secrete a large number of cytokines, thus enhancing the mobility of embryonic trophoblast cells, which has the potential to help embryos invade the endometrium and improve the implantation rate of embryos.
Professor Li Xinyang said that a 40-year-old Miss A had 10 IVF treatment in other hospitals, and also had PGS for embryo chromosome diagnosis, which confirmed that there was no abnormality in the embryo, but she never succeeded in getting pregnant. Later, I learned that curettage might increase the implantation rate of embryos and went to Taipei Rongzong to seek a child.
After Miss A went to Taipei Rongzong, she adopted a new method of follicle induction. Only three shots were given before the egg broke, and eight eggs were obtained. Five eggs were fertilized successfully and the embryo quality was excellent. After curettage, prepare the high-quality endometrium, and then implant the thawed embryo. You only need one successful pregnancy and successfully give birth to twin sons! The artificial reproduction adopted this time is only one more procedure than before, which is a great blessing for infertile couples.
Artificial reproduction breakthrough, mesenchymal stem cells assisted implantation. Professor Zhou Zushu said that embryo implantation is a complicated process. In this process, the blastocyst is close to the time of fertility? After the endometrium, the blastocyst will be activated and adhered, and then move and invade the endometrium.
The interaction between blastocyst and endometrium is very important for embryo implantation, but its regulatory mechanism has not been clarified. This study found that the secretory products of endometrial stromal cells during the critical period of implantation are rich in growth factors and cytokines, which can promote the proliferation and migration of trophoblast cells; Mesenchymal stem cells also secrete a large number of cytokines, thus improving the mobility of embryonic trophoblast cells. These hormones are rich in growth factors, which really help to repair the endometrium, thus increasing the implantation rate.
Professor Li Xinyang pointed out that this research result can be used in artificial reproduction technology. It is predicted that before and after embryo implantation, the embryo will be secreted by endometrial stromal cells or mesenchymal stem cells at the critical stage of implantation, which may enhance the proliferation and mobility of embryonic trophoblast cells to invade the endometrium, thus improving the embryo implantation rate and helping many infertile couples.