The story is set in modern San Francisco. Gene scientist Will Rodman (james frank) has developed a drug to treat human nervous atrophy diseases, which can treat diseases such as Alzheimer's disease. When the new drug is tested on chimpanzees, it is found that it can greatly improve their intelligence, and the symptoms turn green, and their intelligence reaches human level. After giving birth to a baby gorilla, this successful chimpanzee attacked the staff and was shot. Later, the institute was forced to euthanize all the remaining chimpanzees, and the research project was forced to stop. In order to save the newborn baby orangutan, Will adopted him and named him Caesar (andy serkis). In the process of feeding Caesar, Will Rodman met the zoologist Caroline (Freda Toto) and fell in love because of treating the orangutan's injury. Because Caesar inherited his mother's genes, he had high wisdom since he was a child and lived happily with Will's family. After seeing Caesar's experimental effect, Will injected the same drug into his father with Alzheimer's disease, which miraculously restored his brain function. But several years later, Will found that the human body had produced antibodies to this virus drug, and Will's father's condition deteriorated. Will showed his boss the results of the drug, asked to use a more violent virus for the experiment, and succeeded in the orangutan experiment. Will brought the drug home. After an accidental injury to human beings, Caesar was forced to separate from Will and was sent to a nursing home. There he was treated mercilessly, and then he became hostile to human beings. Caesar, with great wisdom, successfully escaped from the nursing home, returned to Will's home, stole the medicine, took it back to the detention center for other chimpanzees to use, and began to lead them, eventually leading other chimpanzees to escape from the detention center. At this time, it has been proved that this drug is a deadly virus to human beings, but it is harmless to orangutans and can greatly improve their wisdom. The virus has begun to spread, the situation is reversing, and a war that has to be opposed to human beings is about to begin.