Contents 1 Pinyin 2 English reference 3 Overview 4 "Treatise on Febrile Diseases" prescription of Danggui Sini Decoction 4.1 Composition 4.2 Function and Indications 4.3 Usage and dosage of Danggui Sini Decoction 4.4 Prescription 4.5 Application 4.6 Modern indications 4.6. 1 Thromboangitis obliterans 4.6.2 Pulseless syndrome 4.6.3 Raynaud's phenomenon and Raynaud's disease 4.6.4 Poliomyelitis 4.7 Pharmacological effects of Danggui Sini Decoction 4.7.1 Effect on immune function 4.7.2 Anti-inflammatory and antioxidant Effect 4.7.3 Effect on heart, blood vessels and blood rheology 4.7.4 Sedation, analgesia and effect on nervous system function 4.7.5 Effect on pathogenic microorganisms 4.8 Discussion by various experts 4.9 Song 4.10 Source 5 Ming Fangxian "Danggui Sini Decoction" 5.1 Prescription 5.2 Functions and Indications 5.3 Usage and Dosage of Danggui Sini Decoction 5.4 Source 6 "Danggui Sini Decoction" Volume 18 of "Health Treasure Book" 6.1 Prescription 6.2 Preparation Method 6.3 Functions and Indications 6.4 The usage and dosage of Danggui Sini Decoction 6.5 Source 7 "Six Books on Medicine" Volume 24: Danggui Sini Decoction 7.1 Prescription 7.2 Function and Indications 7.3 The usage and dosage of Danggui Sini Decoction 7.4 Various explanations 7.5 Source 8 "Re-edited Popular "Treatise on Febrile Diseases" prescription of Danggui Sini Decoction 8.1 Composition 8.2 Efficacy and Indications 8.3 Usage 8.4 Discussions by various experts 8.5 Source 9 "Xingyuan" Vol. Attached reference materials: 1 Danggui Sini Tang in ancient books 1 Pinyin
dāng guī sì nì tāng 2 English reference
Danggui Sini Tang [21st Century Bilingual Science and Technology Dictionary]
danggui sini decoction [Traditional Chinese Medicine Terminology Approval Committee. Traditional Chinese Medicine Terminology (2004)] 3 Overview
There are about six prescriptions with the same name of Danggui Sini Decoction, among which the one recorded in "Treatise on Febrile Diseases" is the commonly used prescription. , which consists of 12g of angelica root, 9g of cinnamon twig, 9g of peony, 3g of asarum, 6g of licorice, 6g of Tongcao, and 8 jujubes. It has the effect of warming the middle, warming the meridians and dispersing cold, nourishing the blood and unblocking the meridians. It is mainly used to treat blood deficiency and cold syndrome caused by blood deficiency and cold, and cold evil stagnation in the meridians. It is a representative prescription for treating blood deficiency and cold syndrome. In modern times, it is commonly used to treat thromboangiitis obliterans, Raynaud's disease, infantile paralysis of the lower limbs, and asymptomatic syndrome. Pulse syndrome, chilblains, women's dysmenorrhea, etc. are caused by blood deficiency and cold coagulation. 4 "Danggui Sini Decoction" prescribed in "Treatise on Febrile Diseases"
The various effects listed in the therapeutic mechanism of this prescription can directly address the pathogenesis of thromboangiitis obliterans, pulseless syndrome, and Raynaud's disease, but it is not effective for The treatment mechanism of symptoms such as cold hands and feet, heavy and thready pulse, or thin and heartbreaking pulse caused by poliomyelitis in children needs further study [1]. In addition, for severe cases, it is necessary to use modern medical thrombolytic therapy and immune preparations [1].
4.1 Composition
Three liang each of angelica root, cassia twig, peony root, and asarum, two liang each of Zhigancao and Tongcao (now Akebia), and twenty-five jujubes (One method, twelve pieces) [2].
Angelica 12g, cassia twig 9g, peony 9g, asarum 3g, licorice 6g, Tongcao 6g, 8 jujubes [3]
Three ounces of angelica, three ounces of cinnamon twigs (peeled), 3 liang of peony root, 3 liang of asarum, 2 liang of licorice (broiled), 2 liang of Tongcao, and 25 jujubes (break, 1 method, 12 pieces) [4]. 4.2 Efficacy and Indications
The Danggui Sini Decoction prescribed in "Treatise on Febrile Diseases" has the functions of warming the meridians and dispersing cold, nourishing the blood and unblocking the meridians [2]. It is mainly used to treat those with blood deficiency and cold, cold hands and feet, pale tongue with white coating, thready pulse, or irregular menstruation caused by blood deficiency and cold coagulation, cold pain in the epigastrium and abdomen, and cold in the collaterals, waist, thighs, legs, and Foot pain; in modern times, it is also used for digital arterial spasm (Raynaud's disease) and the onset of chilblains [2].
The Danggui Sini Decoction prescribed in "Treatise on Febrile Diseases" has the effects of warming the middle, warming the meridians and dispersing cold, nourishing the blood and unblocking the meridians. It mainly treats blood deficiency and cold syndrome. Symptoms include blood deficiency and cold, cold hands and feet, lack of thirst, or pain in the waist, thighs, legs, or feet, or numbness, pale tongue with white coating, deep and thin pulse or thin and desperate pulse, and to treat cold entering the meridians, it is currently used In early stages of Raynaud's disease and frostbite. 4.3 Usage and dosage of Danggui Sini Decoction
Decoct in water, remove residue, and take it in three times [2].
Take 8 liters of water, boil 3 liters, drain, take 1 liter warm, 3 times a day.
Take eight liters of water, boil three liters, remove the dross, take one liter warmly, three times a day [4] 4.4 Prescriptions
In the prescription, angelica and peony are used to regulate liver blood; cinnamon Twigs and asarum warm the meridians and dispel cold; roasted licorice and jujube nourish the spleen and replenish qi and blood; Gui Gui and Paeony can harmonize the nutrient and health; Akebia synergizes with other medicines and unblocks the blood vessels [2]. All medicines are combined to form a warm, nourishing and dredging agent [2].
This prescription is intended to treat symptoms of cold hands and feet and a thready pulse [5]. This syndrome is caused by blood deficiency and cold, blood is cold and stagnant, the blood is weak and does not nourish the limbs, and the cold blocks the Yang Qi and cannot warm the four ends, resulting in cold hands and feet and a thready pulse [5]. However, although the pulse is thin and there are no other signs of yang and yin excess, it can be seen that the cold is in the meridians and the blood vessels are unfavorable [5]. At this time, it is necessary not only to warm the meridians and dispel cold, but also to nourish the blood and unblock the meridians [5]. This recipe is composed of Guizhi decoction without ginger, doubled jujube, and added Angelica sinensis, Tongcao, and Asarum [5]. For blood deficiency and cold coagulation, use Angelica sinensis, which is sweet and warm, to enter the liver and nourish the blood. It is an important medicine for warming and tonifying the liver meridian. Guizhi is pungent and warm, warming the meridians and unblocking the meridians, so as to remove the cold evil retained in the meridians and smooth the blood flow. 2. The medicinal function of 2 is to nourish the blood and warm the blood [5]. White peony root and asarum are used as ministers. White peony root nourishes blood and nourishes nutrients. It is combined with angelica root to nourish and nourish blood. Together with cinnamon twig, it harmonizes qi and blood internally. Asarum is pungent and warm, externally warms the meridians, internally warms the internal organs, and connects the exterior and interior. To dispel cold evil, cinnamon twig can help warm the meridians and dispel cold [5]. Tongcao is used as a supplement to unblock the meridians [5]. Licorice and jujube are sweet in taste, replenishing qi and strengthening the spleen, and can be used to harmonize various medicines. Jujube is used heavily, which not only helps to nourish the blood, but also prevents the dryness and strongness of cinnamon and pungent substances from damaging the yin and blood, so it is recommended [5]. The combined use of all medicines is warm but not drying, tonic but not stagnant, and has the effect of warming the meridians and unblocking the meridians, replenishing the yin and blood, eliminating cold, invigorating the yang, unblocking the meridians, warming the hands and feet, and rejuvenating the pulse [5].
The ratio of cinnamon twig and peony in this prescription is 1:1. The cinnamon twig warms the meridians and unblocks the meridians, and the combination with angelica is a way to nourish blood and warm the blood. The peony nourishes and nourishes the blood and helps the angelica to replenish the blood [3]. 4.5 Application
Danggui Sini Decoction is a representative prescription for treating blood deficiency and cold syndrome [3]. For patients with clinical manifestations such as coldness in the hands and feet, pale tongue with white coating, heavy and thready pulse or thready and heartbreaking pulse, this prescription can be used for modified treatment [3].
Addition and subtraction: If the pain in the waist, thighs, legs, and feet is due to blood deficiency and cold coagulation, add Sichuan root, Achyranthes bidentata, Millet Spatholobi, etc. to activate blood circulation, remove blood stasis, and relieve pain; for women with dysmenorrhea, it is due to blood deficiency and cold coagulation. For men with cold hernia, testicular pain, cold pain in the lower abdomen, cold limbs and stringy pulse, add Cyperus cyperus, cyperus cyperus, etc. to warm the menstrual flow, promote qi and relieve pain; or for men with cold hernia, testicle pain, cold pain in the lower abdomen, cold limbs and stringy pulse, add cyperus cyperus, fennel, galangal, cyperus etc. to regulate qi and relieve pain; For frostbite on the hands and feet, whether it has not ulcerated in the early stage or has ulcerated, Qianghuo, Duhuo, Angelica dahurica, etc. can be added to dispel cold and relieve pain [3]. Adding Evodia and Ginger can also treat patients with chronic cold and vomiting caused by drinking water. It can also be used to treat abdominal pain during menstruation due to blood deficiency and cold coagulation in women, cold hernia, testicular pain, and cold pain in the lower abdomen due to traction in men. 5].
Note on use: This prescription is only suitable for cold limbs due to blood deficiency and cold coagulation. It should not be used for limb syncope caused by other reasons. This prescription is contraindicated for those with damp-heat numbness and pain.
Treating blood paralysis with Danggui Sini Decoction: Patient Zhou, female, 25 years old. When I woke up from a night sleep, my hands were numb, as if they were crawling with ants, my fingers had difficulty moving, and it was inconvenient to hold the needle, but my grip strength was still there. The hands are slightly cold, and there is no change in tactile and pain sensation. The pulse is heavy and thin, slightly stringy and tight, and the tongue is pale and has white coating. When the cold evil is stagnant, the meridians are blocked, the blood flow is not good, and the limb collaterals are out of nourishment, treat it with this prescription plus Chuanxiong, Astragalus, and Ephedra. Symptoms were relieved after two doses and recovered after three more doses.
Danggui Sini Decoction treats early Raynaud's disease: the pathogenesis of this disease is that the Yang Qi is weak and cannot warm and nourish the four ends, cold evil attacks externally, and blood vessels are stagnant. When it comes to warming yang, activating blood circulation, and dispelling cold, Danggui Sini Decoction is quite suitable. Two cases were treated with this prescription. One case was cured by adding moxa leaves and safflower to the original prescription and taking more than 30 doses; the other case was cured after taking 18 doses. No recurrence was found during follow-up.
Treating thromboangiitis obliterans with Danggui Sini Decoction: 10 cases in this group. Symptoms include coldness in the lower limbs, severe pain, and thin and astringent pulse. The course of the disease lasted from 2 months to 3 years. Treat with this prescription combined with Qifu Decoction and Simiao Yong'an Decoction. Results: 9 cases recovered and 1 case improved.
Treat frostbite with Danggui Sini Decoction: Zhao, male, over 30 years old. In the wind and snow, he was frozen to the ground and crawled for several miles. He lay on the ground and waited for death. When his neighbors found him, he carried him back. His hands and feet were backwards and it was difficult to turn his side. For frostbite, use this prescription to measure the temperature of the limbs. After four doses, purple blisters appeared on the body like walnuts, which turned into frostbite. It will be able to rotate after a few days, and it will heal after a month. ("Yuemei Traditional Chinese Medicine Case Collection") 4.6 Modern Indications
[6]
Danggui Sini Decoction is suitable for thromboangiitis obliterans, pulseless syndrome, Raynaud's disease, and children Paralysis of lower limbs, etc. are caused by blood deficiency and cold coagulation. 4.6.1 Thromboangitis obliterans
Thromboangitis obliterans is an inflammatory, staged and periodic chronic occlusive disease involving blood vessels, mainly affecting small arteries and veins in the limbs. , especially blood vessels in the lower limbs. The exact cause of the disease is not yet clear, but may be related to the following factors: ① External factors, such as smoking, cold, dampness, chronic injury and infection. Tobacco infusion can cause vasculitis in experimental animals. ②Internal factors, autoimmune dysfunction, antinuclear antibodies can be found in the patient's serum, immunoglobulin and C3 complex can be found in the arteries, which all support the relationship with immunity; sex hormone and prostaglandin imbalance, and heredity may also be related to the disease.
Pathological changes usually begin with the involvement of arteries and veins, and develop from distal to proximal. The lesions are distributed in stages. The active stage is full-thickness non-suppurative inflammation of blood vessels, proliferation of endothelial cells and fibroblasts, and luminal thrombosis and occlusion; in the later stage, The inflammation subsides and new capillaries are formed. The main clinical manifestations are cold sensitivity of the affected limb, lowered skin temperature, pale skin or cyanosis, abnormal sensation, pain in the affected limb, and nutritional disorders due to ischemia and hypoxia over time. In severe cases, Ischemic ulcer or gangrene, disappearance or weakening of arterial pulse when touched, etc. 4.6.2 Pulseless syndrome
Pulseless syndrome actually refers to Takayasu arteritis, which is a stenosis or occlusion of arteries in different parts caused by chronic progressive and non-specific inflammation of the aorta and its main branches. It can occur in a few cases. Arterial dilation or aneurysm, ischemia in the corresponding part, and subclavian artery occlusion leading to the disappearance of radial artery pulse are often called "pulseless syndrome." The cause is still unknown, but it is thought to be related to genetics, endocrine abnormalities, and immune dysfunction after infection. It mainly affects elastic arteries, most of which invade 1 to 3 arteries. The lesions are more obvious at the beginning of the aortic branches, starting from the middle layer and adventitia of the artery and affecting the intima. The full-thickness arterial wall shows staged irregular proliferation and fibrosis. , varying degrees of stenosis or occlusion of the lumen, coupled with thrombosis, and the basic lesions are exudation, chronic non-specific inflammation and granuloma. The main clinical manifestations are systemic symptoms such as fever, general malaise, and weight loss. Patients with aortic arch syndrome present with dizziness, headache, blurred vision, repeated syncope, convulsions, hemiplegia, numbness and soreness of the corresponding limbs, weakened or disappeared arterial pulsation, and impaired limbs. Lowered blood pressure. ①Thoracoabdominal aortic type: Symptoms include lower limb ischemia, weakness, coldness and soreness in both lower limbs, claudication, vascular murmurs can be heard in the abdomen, and lower limb blood pressure < upper limb blood pressure. ②Pulmonary artery type: manifests as palpitations, shortness of breath, and murmur in the pulmonary valve area. ③Extensive type: Corresponding symptoms of corresponding tissues and organs appear in the corresponding parts of blood vessels. 4.6.3 Raynaud’s phenomenon and Raynaud’s disease
Raynaud’s phenomenon and Raynaud’s disease refer to the skin of the fingers (toes) appearing pale, then purple and red, accompanied by local chills after the patient is exposed to cold or nervousness. Short-term clinical phenomena such as paresthesia and pain often occur repeatedly. Those with no other primary disease are Raynaud's disease, and those with clear secondary disease are Raynaud's phenomenon. There is no consensus on the cause. Some people believe that it is caused by excessive sympathetic nerve activity. Some people believe that it is caused by lesions in the arterial wall causing peripheral blood vessels to overreact to cold, emotional stress, etc. It is currently believed that abnormal function of vascular endothelial cells is the pathophysiological basis of this disease. There are no pathological changes in the early stage. In older patients, the vascular endothelium thickens, the distal finger pulp atrophies, and the distal bone is absorbed. In severe cases, fingertip ulcers and gangrene may occur. 4.6.4 Poliomyelitis
Poliomyelitis is an infectious disease spread by the poliovirus through the digestive tract or respiratory tract. After the virus invades the human body, it invades the nervous system through secondary viremia. , leading to damage to motor neurons in the anterior horn of the spinal cord, causing neuronal cell disease, local tissue congestion, edema, and perivascular inflammatory infiltration. In severe cases, nerve cell necrosis and scar formation result in permanent paralysis, mostly manifested as asymmetrical single limbs. The sequelae of flaccid paralysis include muscle atrophy of the affected limb, limb deformity, and decreased skin temperature. 4.7 Pharmacological effects of Danggui Sini Decoction
[7] 4.7.1 Effect on immune function
The monarch medicine Angelica sinensis has a significant promoting effect on the body’s immune function, and its active ingredients It is an immunoactive polysaccharide from Angelica sinensis, which has immune adjuvant-like activity. It activates complement through the classic pathway and has good complement activity. It also has good interferon-inducing activity; the immunoactive polysaccharide from Angelica sinensis can also significantly improve the functional activity of mononuclear phagocytes. , increase NO content, enhance its ability to secrete TNFα and IL1, and have an antagonistic effect on the inhibitory effect caused by glucocorticoids; Angelica polysaccharide for immune activity has a strong activation effect on lymphocytes and promotes mitosis on human spleen cells. Active, it can differentiate B lymphocytes to different stages of maturity, and some cell groups mature into antibody-secreting cells; Angelicae immunologically active polysaccharides can also directly activate T lymphocytes involved in antibody reactions, enhance the function of cytotoxic T cells, and increase their killing activity. Significantly promotes spleen lymphocyte proliferation. Not only that, the ferulic acid contained in Angelica sinensis has a broad-spectrum anti-allergic effect without inhibiting immune function; ferulic acid has an inhibitory effect on type I, II, III, and IV allergies, and inhibits type I allergy. It may be related to its ability to stabilize cell membranes, inhibit mast cell degranulation and reduce the release of inflammatory mediators; type II allergic reactions are skin vasculitis, active and passive Arthos reactions belong to type III allergies, and the inhibition of type II and III allergic reactions may be related to the effects of angelica Related to anti-inflammatory effects. Guizhi can inhibit complement activity on heterophilic antibody reactions, inhibit mast cell degranulation caused by IgE, and inhibit the release of allergic mediators such as histamine, so it has a strong anti-allergic effect.
The total glucosides of white peony contained in the decoction of the ministerial drug white peony has a direct activating effect on macrophages. Further studies have found that the total glucosides of white peony exert a biphasic regulatory effect on macrophages; in vivo and in vitro experiments have shown that the total glucosides of white peony have an effect on T Cell function shows a function- and concentration-dependent biphasic regulatory effect; the biphasic regulatory effect on humoral immunity is also related to the influence of total glucosides of paeony on T regulatory cells, that is, the positive and negative regulation of total glucosides of paeony on antibody production and its effect on T regulatory cells. It is related to the regulation of TH and TS. Total glycosides of paeony can normalize the cellular immune function in a low immune state. The biphasic regulatory effect of total glycosides of paeony on the pituitary-adrenal axis may be another way in which it regulates immune function. In addition, the acidic polysaccharide PeonanSB and the neutral polysaccharide PeonanSA isolated from white peony root both have activation effects on the reticuloendothelial system. The total polysaccharides of Tongcao can increase serum lysozyme activity, improve the reticuloendothelial system and monocyte phagocytosis function, increase serum antibody levels, and inhibit delayed allergic reactions. Jujube can improve the phagocytosis function of the mononuclear-phagocytic cell system in the body, promote hemolysis and hemolytic plaques, promote lymphocyte transformation and increase the decomposition of peripheral blood lymphocytes, promote lymphocyte proliferation, and has obvious anti-complement activity and anti-type I allergy. effect. Glycyrrhizin can inhibit the release of histamine from mast cells and enhance the ability of lymphocytes to secrete IL2 induced by ConA; glycyrrhetinic acid can increase the lymphocyte ratio; glycyrrhetinic acid diamine can increase serum INFα levels; β-glycyrrhetinic acid is a human Inhibitor of the classical pathway of complement; licorice not only induces interferon and enhances the activity of NK cells, but also contains glycyrrhizic acid that inhibits mast cell degranulation and has anti-allergic effects. Glycyrrhizic acid can also increase the weight of the spleen and thymus, strengthen the network The activity of the endothelial system significantly increases the production of antibodies in the body; licorice polysaccharide can inhibit lymphocyte proliferation. Licorice Lx can not only inhibit the immune response of macrophages, but also reduce the amount of antigen to show immunosuppressive effects, preventing and treating penicillin allergy. Sexual shock. Asarum decoction has an inhibitory effect on both cellular immunity and humoral immunity, but it can inhibit the release of allergic mediators and inhibit immediate allergic reactions. It can be seen that most of the medicinal flavors in this prescription have a promoting, enhancing and regulating effect on immune function. Only Asarum has an inhibitory effect. However, the powerful biphasic regulating effect of white peony root in the prescription can restore the balance of the above effects and the body's immune disorders. . More importantly, the stimulating effect of licorice on the pituitary-adrenocortical axis and the hydrocortisone-like effect of glycyrrhizic acid can increase corticosteroids in the body. Its superior "allowing" effect can coordinate the functions of other hormones throughout the body, improving The body's endocrine regulation ability plays a therapeutic role in "strengthening and strengthening the foundation".
The effect of this prescription on immune function can cut into the immune mechanism of thromboangiitis obliterans, pulseless syndrome, Raynaud's disease and other diseases. 4.7.2 Anti-inflammatory and antioxidant effects
The royal medicine Angelica sinensis has anti-inflammatory, antioxidant, anti-radiation, and anti-chemical damage effects. Angelica decoction can treat acute and chronic diseases caused by various pro-inflammatory agents. It has a significant inhibitory effect on inflammation, and can reduce the release of PGE2 in inflammatory tissues and reduce the hemolytic activity of the complement alternative pathway; Angelica sinensis has a strong scavenging effect on superoxide anions and hydroxyl radicals, and Angelica sinensis decoction has a strong effect on human blood. It has a very significant activating effect on SOD and Ca2+ATPase activity in the brain, inhibiting lipid peroxidation; Angelica sinensis injection can inhibit the production of plasma TXB2, increase the plasma 6KetoPGFⅠα level, correct the ratio of TXA2/GGI2 in cerebral ischemia, and reduce Cerebral ischemia mortality. Guizhi has an inhibitory effect on all aspects of inflammation caused by a variety of inflammatory substances, and can significantly reduce capillary permeability, exudation, edema and granulation tissue hyperplasia. The ministerial drug peony has a significant anti-inflammatory effect, and its active ingredient is total paeony glycosides, which can inhibit the excessive secretion of IL1, TNF, and PGE2, increase the activity of SOD and GSHPx, and reduce the level of MDA; it is effective against experimental non-specific inflammation and immune inflammation. It has an obvious inhibitory effect, and has different inhibitory effects on different aspects of capillary hyperpermeability, exudation, edema, and proliferation of inflammation; peony extract has the effect of enhancing resistance to hypoxia and reducing overall oxygen consumption. And lower body temperature; total glucosides of peony and paeonosin contained in it have a scavenging effect on superoxide anions and hydroxyl radicals. Paeonosin can significantly inhibit the formation of liver lipid peroxides and the increase in SPT. The volatile oil contained in Asarum has obvious anti-inflammatory effects. In addition to enhancing the function of the adrenal cortex and promoting the release of ACTH, its mechanism of action can also inhibit the release of inflammatory mediators during inflammation, fight against inflammatory mediators, and have strong elimination The ability of superoxide anions and the inhibition of hepatic lipid peroxidation have a protective effect on the superoxide anion-induced depolymerization of hyaluronic acid and amino polysaccharides in arthritis. Therefore, it has a significant effect on all links and different stages of inflammation. inhibitory effect. Tongcao has obvious anti-inflammatory and swelling effects, increases blood SOD activity, and reduces LPO content in blood and liver. The jujube polysaccharide contained in jujube can increase the activity of SOD and CAT in whole blood, scavenge free radicals, reduce the content of MDA and LPO in the brain, liver, and blood, scavenge reactive oxygen species in whole blood chemiluminescence, and inhibit oxidative damage. Licorice has an anti-inflammatory effect like phenylbutazone or hydrocortisone. Its anti-inflammatory components are glycyrrhizic acid and glycyrrhetinic acid, which inhibit exudation, edema, granulation tissue hyperplasia and other diseases by inhibiting PGE2 and reducing endogenous PGE2 production. It has an inhibitory effect on stages I, II, and III of inflammation, and can also inhibit allergic inflammation such as Arthus phenomenon and Schwartzman reaction.
The inhibitory mechanism of licorice on immune inflammation may be related to the following three factors: first, inhibiting the activation of the fibrinolytic system; second, reducing the promotion effect of serum on capillary permeability; third, inhibiting the hyperpermeability of cell membranes. Glycyrrhizic acid and glycyrrhetinic acid can also inhibit the generation of free radicals and lipid peroxides and have antioxidant effects, which are very important for the treatment of shock and myocardial infarction. 4.7.3 Effects on the heart, blood vessels and blood rheology
Angelica sinensis has obvious anti-arrhythmic effects, which can slow down conduction, extend the effective refractory period, eliminate reentry, and extend the plateau period. Inhibits ectopic rhythm points and increases fibrillation threshold; Angelicae can increase coronary blood flow, reduce the scope of myocardial infarction caused by coronary occlusion, has a protective effect on myocardial cells from glucose deficiency and hypoxic injury, and can also resist free radicals , reduce oxygen consumption; it can stabilize myocardial cell membranes and protect the function of mitochondria, namely lysosomes; Angelicae injection can exert a protective effect on hypoxic pulmonary hypertension by stimulating β-receptors; Angelicae can significantly inhibit platelet aggregation and reduce blood pressure. It can reduce blood flow viscosity, reduce plasma fibrinogen, prolong prothrombin time, and have anti-thrombotic effects; it has been reported that 5% Angelicae Injection can treat thromboangiitis obliterans for 4 weeks, with an effective rate of 89%. Guizhi can increase coronary blood flow, increase myocardial nutritional blood flow, reduce the incidence of ischemia-reperfusion myocardial ventricular fibrillation, reduce the production of myocardial LDH, CPK, and LPO, increase SOD activity, reduce whole blood viscosity, and reduce fibrin. Original content, antithrombin, inhibits platelet aggregation, dilates blood vessels, and improves peripheral circulation. White peony water extract can antagonize myocardial ischemia caused by pituitary hormone, dilate coronary arteries, increase myocardial nutritional blood flow, dilate blood vessels, and inhibit platelet aggregation induced by ADP and arachidonic acid; total glycosides of paeony can also Reduce the wet weight of platelets and thrombus and inhibit thrombosis. Asarum volatile oil has a positive inotropic and positive frequency effect on the heart, which can increase coronary blood flow; the racemic methyl agenate contained in asarum has the effect of strengthening the heart and dilating blood vessels, and can increase the mean artery of animals in shock. blood pressure, left ventricular systolic blood pressure, coronary sinus blood flow, and reduce central aortic pressure. The licorice flavonoids contained in licorice can reduce the scope of myocardial infarction and antagonize arrhythmias caused by various causes; glycyrrhetinic acid has an agonist-like effect on angiotensin II AT1 receptors; licorice has an anti-atherosclerotic effect, and glycyrrhizic acid inhibits Phospholipase A2 activity and platelet aggregation. These effects of this prescription are beneficial to the treatment of vascular stenosis and occlusion. 4.7.4 Sedation, analgesia and effects on nervous system function
The royal medicine Angelica sinensis has sedative and analgesic effects. Angelica sinensis can expand cerebral blood vessels, improve cerebral circulation, improve neuron metabolism, and reduce the scope of cerebral infarction. , promotes nerve growth and repair-related proteins after cerebral ischemia injury, promotes the expression of nerve cell adhesion molecules and microvessel-related proteins, reduces cell apoptosis, inhibits cell apoptosis in the penumbral zone by promoting the expression of bcl2; promotes nerve Regeneration and reinvention. The cinnamic aldehyde contained in cinnamon twig has obvious sedative effect, has a certain analgesic effect, and has antipyretic and anticonvulsant effects. The ministerial drug white peony has obvious analgesic effect, and paeoniflorin and licorice FM100 also have significant analgesic and sedative synergistic effects. The combination of peony and licorice can treat central or peripheral muscle spasm and pain caused by spasm; white peony also has Anticonvulsant effect. Asarum volatile oil has obvious central inhibitory effect, small-dose sedation, large-dose hypnosis and anticonvulsant. Its effect on the cerebral cortex, hippocampus, midbrain reticular structure, etc. is similar to barbiturates, and its analgesic intensity is similar to that of amotidine. I'm pretty sure. Asarum decoction also has analgesic effects. Tongcao has obvious antipyretic effect. Jujube has a hypnotic and sedative effect. Licorice has a poppy-like specific antispasmodic effect, and therefore has a spasmodic effect. Licorice FM100 has sedative, analgesic, and anticonvulsant effects; licorice flavonoids have a protective effect on cerebral ischemia and reperfusion; intravenous infusion of glycyrrhizic acid can improve Ischemia-reperfusion reduces brain mitochondrial ATPase and brain tissue lactate dehydrogenase activity, reducing cerebral edema. Human body surface area calculator BMI index calculation and evaluation Female safe period calculator Pregnancy date calculator Normal weight gain during pregnancy Safety classification of medication during pregnancy (FDA) Five elements and eight characters Adult blood pressure evaluation Body temperature level evaluation Diabetes diet recommendations Common clinical biochemistry units Conversion to basal metabolic rate Calculate sodium supplementation calculator Iron supplementation calculator Commonly used Latin abbreviations for prescription Quick check Common symbols for pharmacokinetics Quick check Effective plasma osmolality calculator Ethanol intake calculator
Medical encyclopedia, calculate now! 4.7.5 Effect on pathogenic microorganisms
Angelica sinensis decoction has inhibitory effects on Escherichia coli, Salmonella typhi, Salmonella dysenteriae, Salmonella diphtheriae, Staphylococcus aureus, and Pseudomonas aeruginosa. Guizhi volatile oil is effective against Bacillus anthracis, pneumococcus, Escherichia coli, Proteus, Vibrio cholerae, Salmonella, Shigella, typhoid and paratyphoid bacteria, Staphylococcus aureus, Staphylococcus albus, Mycobacterium tuberculosis, orphan virus, influenza virus and Syphilis has inhibitory effect. In vitro tests of white peony root decoction have inhibitory effects on a variety of pathogenic bacteria. In addition to some of the above-mentioned bacteria, it has inhibitory effects on Shigella dysentery, hemolytic Streptococcus, viridans Streptococcus, Streptococcus pneumoniae, Pseudomonas aeruginosa, and Bordetella pertussis. , Vibrio cholerae and many fungi have inhibitory effects, and have direct antiviral effects.
Asarum alcohol infusion, volatile oil, and decoction have inhibitory effects on Gram-positive bacteria, Bacillus subtilis, and Salmonella typhi, 16 types of fungi such as Aspergillus aflatoxin, and syncytial viruses. In addition to the inhibitory effect on some of the above-mentioned bacteria, licorice also has inhibitory effects on Helicobacter pylori, amoeba, Clonorchis sinensis, and Trichomonas, and has direct broad-spectrum antiviral effects. Licorice polysaccharide has an inhibitory effect on vesicular stomatitis virus, type Ⅰ herpes simplex virus, and vaccinia virus; glycyrrhizic acid has strong ability to inhibit coxsackie virus, syncytial virus, and adenovirus; glycyrrhizic acid monoamine can inactivate HIV, and glycyrrhizin removes In addition to inhibiting the above viruses, it can also inhibit hepatitis virus. 4.8 Discussions by various schools
1. "Jinjing Neitai Fangyi": If the Yin blood is internally deficient, it will not be able to flourish in the pulse. If the Yang Qi is externally deficient, it will not be able to warm the four ends, so the hands and feet will be cold. The pulse is extremely thready. Therefore, Angelica sinensis is used as the king to nourish blood, and peony is used as the minister to supplement it to nourish Qi; cinnamon twig and asarum are used to dispel cold and dampness; jujube licorice is used as the envoy to benefit and nourish Qi. It's not enough; it's just the lightness of Tongcao that can travel its veins and convulsions.
2. "Selected Notes on Ancient Prescriptions": If the four inverses of Angelicae Sinensis do not use ginger and aphrodisiac, the yin and blood are weak, and there is a fear of severe damage to the yin. Moreover, although the four inverses are cold, they are not cold, and they can only be harmonized. Jueyin only warms the meridians and restores the operation, so the sour and sweet ones are used to relieve the middle part, the pungent and sweet ones are used to warm the surface, and combine the four methods of treating the liver. The pungent of cassia twig is to warm the liver yang, the pungent of asarum is to unblock the liver yin, and the pungent of angelica is used to treat liver yin. To nourish the liver, the sweetness of jujube and jujube can soothe the liver, the acidity of white peony root can purge the liver, and it can be used to unblock the qi of yin and yang and open the collaterals of Jueyin.
3. "Yizong Jinjian": This prescription takes Guizhi Decoction and Angelica sinensis. Jueyin governs the liver and is the blood chamber; asarum is used as an extremely pungent taste, can reach 3 yin, and warms the external meridian. And the internal organs are warmed; Tongcao has a very clear nature, which is good at opening joints, opening the internal organs and opening up the internal organs; adding jujube twice as much is the method of adding sweetness and sweetness to the internal organs; subtracting the ginger, it may be too pungent and cause rapid dispersion. 4.9 Song Jue
Angelica sinensis, cinnamon, peony, date, asarum, licorice and Tongcao; if the blood is deficient, the liver is cold and the limbs are numb, decoction and take this prescription will make you happy [3]. 4.10 Source
"Treatise on Febrile Diseases" 5 "Danggui Sini Decoction" written by Fang Xian of the Ming Dynasty in "The Wonderful Prescription" 5.1 Prescription
Angelica sinensis, cinnamon twig, peony, and asarum, two each Money and a half. Tongcao and licorice cost one and a half qian each. 5.2 Functions and Indications
Danggui Sini Decoction from "Wonderful Prescriptions" written by Fang Xian of the Ming Dynasty is mainly used to treat patients with cold hands and feet and a thready pulse. 5.3 Usage and Dosage of Danggui Sini Decoction
Take one dose with two minutes of water and one red date, boil for one minute and take it at any time. 5.4 Source
Ming Dynasty Fangxian's "Miracle Prescription" 6 "Health Treasure Book" Volume 18 Prescriptions of Danggui Sini Decoction 6.1 Prescription
Angelica tail 2.1 grams Aconite (Pao) ) Guangui Fennel (fried) Bupleurum 1.5g each, Paeony 1.2g Poria, Xuan Husuo and Melia japonica 0.9g each (boiled in wine) Alisma 0.6g 6.2 Preparation method
Apply the medicine. 6.3 Functional Indications
The Danggui Sini Decoction in the 18th volume of "Health Treasures" is mainly used to treat hernia, cold pain in the umbilicus and abdomen, and traction on the waist and hips. 6.4 Usage and dosage of Danggui Sini Decoction
Add 350 ml of water, decoct to 150 ml, remove the dregs, and take it warm on an empty stomach. 6.5 Source
"Health Treasure Mirror" Volume 18 7 "Medical Briefs" Volume 24: Danggui Sini Decoction 7.1 Prescription
Aconite 1 and a half qian (cannon) , Guangui 1 and a half qian, white peony root 1 and a half qian (fried with wine), Bupleurum 5 qian, angelica 3 qian, Evodia 1 qian (fried with vinegar), neem 2 qian (fried with wine), fennel 3 qian (fried with vinegar) Fried), Alisma 1 and a half yuan. 7.2 Function and Indications
The Danggui Sini Decoction in Volume 24 of "Six Books on Medical Treatment" is mainly used to treat hernia due to yang deficiency and cold, and tight and thin pulse. 7.3 Usage and dosage of Danggui Sini Decoction
Decoct in water, remove the phlegm and take it warm. 7.4 Discussions by various schools
Yang is deficient in the lower part and cold is bundled in the meridians. Deficient yang cannot be applied and the menstrual qi is suppressed, so hernia due to deficiency often occurs. Aconite nourishes fire and supports yang, Guan Gui warms the meridians and dispels cold, Angelica sinensis nourishes the blood and strengthens the meridians, White Peony astringes the yin and softens the tendons, Bupleurum raises clear yang to remove evil spirits, Evodia lowers negative qi and lowers it, Alisma purges turbid yin and clears the kidneys. Fennel warms the menstrual qi and relieves hernia, while Melanium japonica purges dampness and heat to relieve hernia due to deficiency. 7.5 Source
"Six Books on Medical Treatment" Volume 24 8 "Re-editing of Popular Treatise on Febrile Diseases" Prescription of Danggui Sini Decoction 8.1 Composition
Whole Angelicae 3 cents, Guizhi tip 5 points, Asarum 3 points (honey roasted), 1 fresh scallion white (cut into inches), raw white peony root 3 qian, Qingzhicao 5 points, Jiangtongcao 1 qian, 1 scoop of Chenshao wine (flush). 8.2 Efficacy and Indications
The Danggui Sini Decoction prescribed in the "Re-edited Treatise on Febrile Diseases" has the effect of nourishing yin and unblocking meridians. It mainly treats coldness in the hands and feet and a thready pulse. 8.3 Application
For those who suffer from cold hernia, severe lower abdominal pain, and foaming at the mouth, add Evodia Fructus to relieve hernia pain and ginger juice to relieve vomiting.
8.4 Discussions by various schools
In the prescription, Gui and Shao Rong nourish the blood collaterals as the king; the ministers use cinnamon and pungent. Pungent unblocks the meridians and makes the meridians unobstructed. The collateral qi can spread all around. It must be supplemented by Jiang. For Tong, scallion, and wine, use one to speed up the passage of the meridians, and use the other to smooth the collaterals; use burnt grass, the pungent taste will help, and the force will be released faster. This is a good recipe for nourishing blood and nourishing yin, activating meridians and unblocking meridians. 8.5 Source
"Revisiting the Popular Treatise on Febrile Diseases" 9 "Xingyuan" Volume Six Directions of Danggui Sini Decoction 9.1 Composition
Angelica 1 qian and 5 cents, Guangui 1 qian and 5 cents, White peony root is 1 cent and 5 cents, asarum is 1 cent and 5 cents, licorice (zhi) is 1 cent, Tongcao is 1 cent and Evodia is 5 cents. 9.2 Functions and Indications
The Danggui Sini Decoction in the Six Prescriptions Volume of "Xingyuan" is mainly used to treat the cases where the yin (stagnation) is as big as a bucket and various medicines are ineffective. 9.3 Usage and Dosage of Danggui Sini Decoction
Use 5 slices of ginger, boil it in water, empty it and take it warmly.
9.4 Source