Contents 1 Pinyin 2 English reference 3 Overview 4 Alias ??of Dahuang Fuzi Decoction 5 Prescription 6 Functions and Indications 7 Usage and dosage of Dahuang Fuzi Decoction 8 Prescription 9 Application 10 Modern indications 10.1 Biliary colic 10.2 Cholecystectomy Syndrome 10.3 Chronic dysentery 10.4 Uremia 10.5 Others 11 Pharmacological effects of Dahuang Fuzi Decoction 11.1 Anti-pathogenic microbial effects 11.2 Anti-inflammatory, antioxidant, and anti-allergic effects 11.3 Effects on the circulatory system and hemorrheology 11.4 Effects on renal function and urology Systemic effects 11.5 Effects on liver, gallbladder and gastrointestinal tract 11.6 Effects on nervous and endocrine functions 11.7 Effects on immune function 12 Discussions by various experts 13 Notes 14 Song instructions 15 Excerpts 16 References attached: 1 Rhubarb and Fuzi Decoction in ancient books 1 Pinyin
dà huáng fù zǐ tāng 2 English reference
Rhei and Aconiti Praeparatae Decoction [Xiangya Medical Professional Dictionary]
Dahuang Fuzi Tang [21st Century Bilingual Science and Technology Dictionary] ]
dahuang fuzi decoction [Traditional Chinese Medicine Terminology Approval Committee. Traditional Chinese Medicine Terminology (2004)] 3 Overview
Dahuang Fuzi Decoction is recorded in the volume of "Jin Gui Yao Lue Prescriptions". It consists of 9g of rhubarb, 12g of aconite, and 6g of asarum. It has the effect of warming the inside and dispersing cold, laxative and relieving pain. It is mainly used to treat internal knots due to internal cold accumulation and abdominal pain due to cold accumulation caused by poor yang qi. It is suitable to be treated with Wenli Powder. Cold, laxative and pain relieving. This prescription is a representative prescription for the treatment of cold syndrome. It is commonly used in modern times to treat acute appendicitis, acute intestinal obstruction, biliary colic, post-gallbladder syndrome, pancreatitis, kidney stones, testicular swelling and pain, sciatica and other gastrointestinal colds. Those who accumulate evidence.
Although the aconite in the formula is a royal medicine, rhubarb is still the main drug for antibacterial, anti-renal failure, and treatment of uremia, biliary colic and post-gallbladder syndrome. Aconite and Asarum can play a positive role in improving uremia, hypertension, heart failure, etc. 4 Alias ??of Rhubarb Aconite Decoction
Rhubarb Aconite Decoction 5 Prescription
Three ounces of rhubarb, three pieces of aconite, and two ounces of asarum [1].
Rhubarb 9g, aconite 12g, asarum 6g[2]
Rhubarb 9g, aconite 9g, asarum 3g[3]
Three ounces of rhubarb, aconite Three pieces (guns) and two ounces of asarum [4]. 6 Functions and Indications
Warming and dispersing cold, laxative and pain relieving. It mainly treats cold accumulation syndrome. Symptoms include abdominal pain, constipation, hypochondriac pain, fever, chills, cold extremities, convulsions in the hands and feet, white and greasy tongue coating, and stringy and tight pulse. [2][1]
Yang deficiency and cold knot, abdominal pain and constipation, hemiplegia under the hypochondriac, fever, cold hands and feet, white and greasy tongue coating, tight and stringy pulse. It is currently used for intercostal neuralgia, sciatica, kidney stones, gallstones, chronic appendicitis, pancreatitis, inguinal hernia and other symptoms mentioned above. People with jaundice have yellow body, slight sweat on the forehead, urination, and black stool. This is because of sexual intercourse injuries and blood accumulation in the lower abdomen, which makes the lower abdomen turn yellow, causing pain in the lower abdomen and lower back. This prescription can actually treat migraine, but it is not just migraine. It can also treat cold hernia, chest and abdominal cramps extending to the chest and waist, scrotal swelling, occasional water sounds in the abdomen, and severe aversion to cold. 7 Usage and Dosage of Rhubarb and Aconite Decoction
Decoction in water and take it three times. After taking it, take another dose like a person walking four or five miles. Functions: Warming the body, dispersing cold, laxative and relieving pain [1].
For the above three flavors, boil 200 ml with 500 ml of water and take it warmly in three portions. If a person is forced to boil 250 ml, take it warmly in three batches, about an hour apart.
Boil 2 liters of 5 liters of water and take 3 servings. If a strong person boils 2 and a half liters, divide the temperature into 3 servings. After taking it, it is like walking 45 miles, taking 1 dose.
Take five liters of water, boil two liters, and take three servings after being warmed up [4]. If you are strong, boil two and a half liters, warm it up and take it three times [4]. After taking it, it is like walking four or five miles, taking one dose [4]. 8 Prescriptions
This prescription is mainly used to treat internal knots due to accumulation of cold in the interior, and abdominal pain due to cold accumulation in the interior caused by poor movement of Yang Qi. The treatment is suitable for warming the interior and dispersing cold, laxative and relieving pain. Aconite in the prescription is pungent and hot, warming yang and dispelling cold; rhubarb cleanses the stomach and intestines, purges and removes stagnation, and is the king medicine. Asarum is pungent, warm and clears, removes cold, dissipates stagnation and relieves pain, and is used as an adjuvant medicine. Although the rhubarb in the prescription is bitter and cold, but with the pungent heat of aconite and asarum, the bitter and cold nature is suppressed, but the effect of diarrhea is still retained. This compatibility method is called "removing its properties and retaining its functions". The combination of 3 medicines can effectively warm the body, dispel cold, relieve constipation and relieve pain.
[2]
Aconite in the prescription is pungent and hot, warms the interior and dissipates cold, treats cold and pain in the heart and abdomen, rhubarb removes accumulated knots, and is the king medicine; Asarum is pungent and warm, dispersing cold and relieving pain, and assists Aconite It is used as a ministerial drug to enhance the effect of dispersing cold. Although the nature and flavor of rhubarb are bitter and cold, when combined with aconite and asarum, which are pungent substances that dissipate heat, the cold nature can be controlled while the purgative nature can be preserved. The three medicines are combined to form a medicine that is warm, dispersing cold and coagulating, and relieves bitterness and pungentness [1].
This prescription is a representative prescription of warming agent. It is mainly used to treat constipation, abdominal pain, migraine under the hypochondriac, fever, and lukewarm hands and feet caused by accumulation of internal cold and stagnant Yang Qi. According to the treatment principle of treating cold with heat, treating knots with dispersion, and attacking with lingering symptoms, it is appropriate to use a combination of warming and dredging. Therefore, the pungent heat of Aconite is used to warm the interior and dispel cold, and relieve pain in the abdomen and hypochondrium. Cold internal knots require warming medicine to remove the cold, and at the same time purgative medicine is needed to remove the knots. Therefore, rhubarb is used as a purgative to cleanse the internal stagnation. Asarum is pungent and warm, dispersing cold and relieving pain. Aconite is used as an adjuvant to help warm the body, dispel cold and relieve pain. Although the rhubarb in the prescription is bitter and cold in nature, but it contains a large amount of the pungent heat of aconite, the bitter and cold nature is suppressed, and the purgative effect is preserved. The three medicines are used together to achieve the effect of lowering the temperature. [3] 9 Application
1. This prescription is a representative prescription for treating Hanjili syndrome. Anyone with clinical manifestations such as abdominal pain, constipation, lukewarm hands and feet, white and greasy coating, stringy and tight pulse, etc. can use this modified method for treatment. [2]
2． Addition and subtraction: If the abdominal pain is severe and the person likes warmth, add cinnamon twigs and white peony root; if the abdomen is distended and the fur is dirty, add Citrus aurantium, Magnolia officinalis and Shenqu; if there is cold pain under the flank, add fennel and cinnamon; if the stagnation is more severe For mild cases, use rhubarb to slow down diarrhea; for those with weak constitution, add Codonopsis pilosula, Angelica sinensis, etc. to replenish qi, nourish blood and replenish deficiency. [2]
3. Notes on use: The sum of the dosage of aconite and asarum in the prescription should be greater than the dosage of rhubarb, in order to achieve the purpose of warming the body, dispersing cold, and purging knots and stagnation. [2]
4. Abdominal pain: A man in his fifties had abdominal pain for several years. After the diagnosis, he found that his heart was hard and there was thunder in his abdomen, so he drank Banxia Xiexin Decoction, but it didn't work. One day, I suddenly felt severe chills and trembling, and my colic was twice as severe as usual, so I drank rhubarb and aconite soup and the pain stopped. After taking it for several days, the disease no longer occurs.
5. Intercostal neuralgia: A 71-year-old man came to the hospital complaining of severe chest pain on the right side. He had a dull complexion, anemia, limited foot movement, and difficulty walking. The pulse is strong and strong, the tongue is moist and uncoated, the abdominal strength is medium and slightly soft, the rectus abdominis muscle is contracted and the patient has bowel movements once every 45 days. I was given Rhubarb and Fuzi Decoction, and the patient went well and recovered within 25 days of taking the medicine.
6. Meniere's syndrome: Qi, female, 40 years old. I suffer from Meniere's syndrome and have frequent attacks. A week ago, due to cold and fatigue, dizziness recurred, vision rotated, bedridden, aggravated by head and body movement, vomiting, phlegm and saliva, swelling and pain 2 inches below the navel, thin diarrhea, indigestion, dry mouth and desire. Drinking, pale tongue, white and thick sticky coating, slippery and slow pulse. In terms of dizziness due to phlegm and water retention, I prepared Alisma Decoction combined with Erchen Decoction with a flavor from "Jin Gui Yao Lue Prescriptions", but the treatment was ineffective. Diagnosis of the tongue again was based on subumbilical pain syndrome, and it was understood that this was Yang deficiency and cold excess, which accumulated in the inside and caused swelling and pain, triple burner congestion, clear Yang did not rise, and turbid Yin did not fall, causing dizziness. Change to rhubarb and aconite soup with added flavors: 8g of aconite, 10g of rhubarb, 6g of asarum and ginseng, 2 doses. After taking the medicine, I had a light laxative, and my dizziness and swelling and pain were reduced by half. After two more doses, all symptoms were eliminated. 10 Modern Indications
[5]
Indications: This prescription is used to treat biliary colic, post-gallbladder syndrome, chronic dysentery, uremia and other patients with cold accumulation. 10.1 Biliary colic
Biliary colic is clinically more common in cholecystitis and biliary tract stones, and the two are causal. Bile viscosity and stasis, bacterial infection, etc. are also important factors. These factors make the lining of the bile duct congested and edematous. , bile duct stenosis or obstruction*** Irregular contraction of the gallbladder is the main mechanism causing biliary colic. 10.2 Post-cholecystectomy syndrome
Post-cholecystectomy syndrome is commonly caused by biliary tract bleeding, which is caused by improper treatment such as blood vessel ligation during surgery. The main clinical manifestations are severe biliary tract bleeding. Abdominal cramps, chills, fever, jaundice, hematemesis, and bloody stools. Post-cholecystectomy syndrome is also common with bile duct injury. The injury site is common at the confluence of the cystic duct, common hepatic duct, and common bile duct. In addition to anatomical variation of the bile duct and anatomical structural disorders caused by inflammation, mucosa, and scar formation in the gallbladder triangle, the main During the operation, the bile duct is mistakenly ligated and transected as the cystic duct, the cystic artery is blindly clamped, and the common bile duct is excessively stretched, causing part of the bile duct wall to be ligated or torn to cause stenosis of the bile duct, resulting in postoperative obstructive jaundice, bile leakage, peritonitis, and Bile duct infection mainly clinically manifests as jaundice, peritonitis, and bile leakage that is difficult to heal. 10.3 Chronic dysentery
Chronic dysentery is mainly caused by incomplete treatment of acute bacillary dysentery. Chronic dysentery is defined as a disease lasting more than 2 months. The causative bacterium is Shigella dysenteriae, and the lesions are mainly in the sigmoid colon and descending colon. The intestinal mucosa is congested, edema, and hemorrhage. The main clinical manifestations are long-term left lower abdominal pain, tenesmus, and bloody and purulent stools. 10.4 Uremia
Uremia is the late stage of renal failure and is more common in patients with chronic renal failure.
Any urinary system disease that destroys the normal structure and function of the kidney can cause renal failure, such as primary and secondary glomerulopathy, obstructive nephropathy, chronic interstitial nephritis, renovascular disease, congenital and hereditary Kidney disease, etc., can all develop into renal failure. The common causes in China are, in order: glomerulonephritis, diabetic nephropathy, hypertensive nephropathy, polycystic kidney disease, obstructive nephropathy, etc. When the glomerular filtration rate drops to about 75% of normal, renal function will continue to decline until uremia occurs. When a certain number of nephrons are destroyed, the metabolic waste excretion load of the surviving nephrons increases. As a result, glomerular capillary hyperperfusion, high pressure, and high filtration occur compensatoryally, resulting in glomerular epithelial cell foot process fusion, mesangial and stromal proliferation, glomerular hypertrophy, and subsequent sclerosis. Damage to the glomerular endothelium induces platelet aggregation, leads to the formation of microthromboses, and promotes glomerulosclerosis; glomerular permeability increases, damaging the renal tubulointerstitium. The three processes continue to form a vicious cycle. At the same time, the increased activity of angiotensin II and renin play an important role in the above process. Due to severe water, electrolyte and acid balance dysfunction in renal failure, the remaining nephrons cannot fully excrete metabolites and uremic toxins (macromolecule nitrogenous substances, medium molecule toxic substances, macromolecular toxic substances) and renal Endocrine dysfunction, resulting in a series of uremic symptoms, such as sodium and water balance imbalance, edema, hyperkalemia, metabolic acidosis, hyperphosphatemia, hypocalcemia, and hypermagnesemia, which in turn can cause hypertension, left ventricular Hypertrophy, heart failure, pericarditis, atherosclerosis, uremic pneumonia, anemia, hemorrhage, neuromuscular symptoms, gastrointestinal symptoms, skin itching, renal dystrophy, endocrine and metabolic disorders, and concurrent infections. 10.5 Others
It is often used to treat acute appendicitis, acute intestinal obstruction, pancreatitis, kidney stones, testicular swelling and pain, sciatica and other symptoms of gastrointestinal cold accumulation. [2] 11 Pharmacological effects of Dahuang Fuzi Decoction
[6] 11.1 Anti-pathogenic microorganism effects
Rhubarb has inhibitory effects on a variety of Gram-positive and negative bacteria, among which the most Sensitive persons include Staphylococcus aureus, hemolytic Streptococcus, Neisseria gonorrhoeae, Bacillus diphtheriae, Bacillus subtilis, Bacillus anthracis, Bacillus typhi and Shigella dysenteriae; they have antibacterial activity against Bacteroides fragilis, an anaerobic bacterium that dominates the intestine. When obstruction or intestinal paralysis occurs, the number in the intestine increases and can easily cause cholecystitis in the duodenum. It has strong antibacterial activity against Helicobacter pylori in the stomach; rhubarb has an inhibitory effect on the adhesion properties of Escherichia coli in pyelonephritis; It has a therapeutic effect on acute suppurative cholangitis infection; rhubarb has an inhibitory or inactivating effect on influenza virus, hepatitis B virus, herpes simplex virus and CMV. Its main antibacterial ingredients are emodin, rhein and aloe-emodin. The adjuvant asarum alcohol extract and volatile oil have inhibitory effects on Gram-positive bacteria, Bacillus subtilis, and Salmonella typhi. The decoction has an inhibitory effect on Mycobacterium tuberculosis and Salmonella typhi. Asarum volatile oil has an inhibitory effect on Aspergillus flavus and Aspergillus niger. , Cladosporium cereus, Candida albicans and other 16 species of fungi all have antibacterial effects. Its main antibacterial active ingredient is sassafras; α-asarone has an inhibitory effect on respiratory syncytial virus. From the above antibacterial and antibacterial spectrum, it can be seen that this prescription has a pathogenic therapeutic effect on biliary tract infections, intestinal infections, urinary tract infections and other diseases. 11.2 Anti-inflammatory, antioxidant, and anti-allergic effects
The monarch drug Aconite has obvious anti-inflammatory activity on multiple aspects of inflammation, such as exudation, edema, and granulation tissue hyperplasia. This anti-inflammatory activity is most Scholars believe that its active ingredients, Aconitum aconitum, Aconitum aconitum, and Aconitum aconitum, stimulate the hypothalamus-pituitary-adrenocortical system and promote the function of the adrenal cortex. At the same time, Aconite itself also has corticosteroid-like effects. The ministerial drug rhubarb can significantly inhibit the lipid oxidase of peritoneal macrophages, reduce the synthesis and release of leukotriene β4 and 5-hydroxyeicosatetraene, the metabolites of arachidonic acid, inhibit cyclooxygenase, and reduce the synthesis of PGE. , can activate monocytes to secrete TNFα, and can coordinate PHA to activate monocytes to secrete IL2 and INFγ, so it has obvious anti-inflammatory activity and is effective in early inflammation exudation, increased capillary permeability, leukocyte migration and inflammatory edema. Obvious antagonistic effect; at the same time, rhubarb can scavenge oxygen free radicals and hydroxyl free radicals, and inhibit the generation of LPO induced by hydroxyl free radicals. It has significant antioxidant effects, and its anti-inflammatory activity is roughly the same as that of aspirin. The adjuvant Asarum volatile oil not only enhances the function of the adrenal cortex, but also has ALTH-like effects. It can also inhibit multiple aspects of the release of inflammatory mediators, and has strong ability to scavenge oxygen free radicals and inhibit lipid peroxidation. It has a protective effect on the depolymerization of hyaluronic acid and aminopolysaccharides in synovial fluid induced by oxygen free radicals. It also has antihistamine and anti-allergic effects, thereby increasing capillary permeability, exudation, and edema caused by inflammation. , WBC migration and granulation tissue proliferation have obvious inhibitory effects. These anti-inflammatory effects are obviously beneficial to the treatment of cholecystitis, post-cholecystectomy syndrome and uremia.
11.3 Effects on the circulatory system and hemorrheology
The racemic desmethyl aconite contained in the monarch drug Aconite has obvious cardiotonic effects, enhances myocardial contractility, and increases cardiac output, especially The cardiotonic effect on heart failure is more obvious; Aconite has a significant anti-bradyarrhythmic effect, can improve atrioventricular conduction, and accelerate the return of heart rhythm to sinus rhythm; Aconite injection can significantly reduce myocardial oxygen consumption and antagonize myocardial ischemia. Blood hypoxia; endotoxin shock can significantly improve the reduction in stroke volume, cardiac output and cardiac index. At the same time, it can improve sinoatrial node function, promote atrioventricular conduction, and exhibit beta receptor agonism and alpha1 receptor agonism. Dual effects of body blocking; Aconite and its compound preparations have obvious anti-shock effects. Aconite has both boosting and antihypertensive effects on blood pressure. Among them, aconite can block α1 receptors and excite β receptors. It has effects on the body and is an effective component for lowering blood pressure; oxidized methyldopamine is an α-receptor agonist, norpogonine has an stimulating effect on both β-receptors and α-receptors, and is an effective component for boosting blood pressure, and Aconite has It has obvious inhibitory and anti-thrombotic effects, thus changing blood rheology. Aconite and its compound preparations Shenfu Decoction and Sini Decoction can increase the effects of hemorrhagic shock, endotoxic shock, cardiogenic shock and other shocks. Blood pressure and anti-shock effects. In addition to lowering blood pressure, lowering blood lipids and strengthening the heart, rhubarb can also inhibit platelet aggregation, inhibit the production of TXA2, anti-thrombosis, and inhibit calcium influx; rhubarb can also inhibit the activity of cell membrane Na+K+ATPase , increase plasma osmotic pressure, transfer tissue water into blood vessels, dilute blood flow, thereby reducing blood viscosity and improving microcirculation, thus improving blood rheology and reducing plasma endotoxin concentration during acute infection. , which is helpful to prevent DIC from occurring. The adjuvant asarum has a positive inotropic and frequency effect on the myocardium, which significantly improves the left ventricular pump function and myocardial contractility. Asarum extract can increase the mean arterial pressure and left ventricular systolic pressure of animals in shock, and reduce the central arterial pressure. It can increase coronary blood flow, prevent myocardial ischemia, protect against hypobaric hypoxia, and dilate peripheral blood vessels. These effects of this prescription should have a certain therapeutic effect on uremia complicated by hypertension and arrhythmia, heart failure, glomerular thrombosis and circulatory disorders, and blood rheology abnormalities. 11.4 Effects on renal function and urinary system
Although the monarch drug Aconite has no direct effect on the kidneys and other urinary systems, its cardiotonic, anticoagulant, anti-myocardial ischemia, anti-shock and other effects are especially suitable for treating uremia. The treatment of heart failure, shock, and hypertension that are complicated by the disease can improve the hypercoagulable state of the renal tubules such as nephritis, nephropathy, and uremia. The ministerial drug rhubarb has a significant therapeutic effect on renal failure, especially uremia. First of all, the emodin, rhubarb anthraquinone and rhein anthrone glucoside contained in rhubarb can inhibit the formation of glomerular mesangial cells and the growth of renal tubular epithelial cells, thereby slowing down the process of glomerulosclerosis; rhubarb also It can stabilize the lysosomal membrane, prevent the influx of cellular calcium ions, resist platelet aggregation, dilate blood vessels, and increase macrophage function, thereby protecting kidney damage; rhubarb can also inhibit compensatory renal hypertrophy. Secondly, in addition to slowing down glomerulosclerosis and hypermetabolism of renal tubules, rhubarb can also regulate lipid metabolism, thyroid function and protein, which can be beneficial to the treatment and treatment of hyperlipidemia, low calcium, high phosphorus, etc. in uremia. Endocrine dysfunction. Third, the purgative effect of rhubarb can be beneficial to the treatment of water and sodium retention and hyperkalemia in uremia, reducing intestinal amino acid absorption, increasing blood amino acids, and increasing protein synthesis R. At the same time, emodin and rhein can Inhibits Na+K+ATPase in the renal medulla, reducing the reabsorption of sodium by the renal tubules; rhubarb extract has the effect of inhibiting the development of renal pathology, significantly reducing urea and creatinine in the blood, disappearing methylguanine, and reducing The state of calcium and high phosphorus is improved, the excretion of urea and creatinine in urine is significantly increased, and the abnormality of renal tubular amino acid transport is corrected; rhubarb tannin can inhibit the decomposition of protein in the body, promote the reuse of nitrogen, eliminate azotemia, thereby effectively improving renal function. The filtration rate of the beads can improve metabolic disorders such as water, electrolyte and acid balance, which is particularly important for the treatment of uremia. In addition to the immunosuppressive effect of the adjuvant asarum on kidney damage caused by immune causes such as nephropathy, its positive inotropic effect can increase coronary blood flow and improve myocardial hypoxia, and its vasodilatory effect can treat uremia. In patients with hypertension and heart failure, the asarin contained in it can inhibit the excretion of urinary protein due to renal injury and improve serum biochemical indicators; the racemic adenosine contained in it has a wide range of physiological effects like an epinephrine beta stimulant. Therefore, it has the effects of strengthening the heart, dilating blood vessels, relaxing smooth muscles, increasing lipid metabolism and raising blood sugar, which is more conducive to the treatment of hypertension, hyperlipidemia, heart failure and metabolic disorders in uremia. 11.5 Effects on the liver, gallbladder and gastrointestinal tract
The monarch drug Aconite decoction can significantly stimulate the spontaneous contraction of the jejunum, has bile-like and histamine-like effects, and is beneficial to jejunal emptying; Aconite decoction It can also inhibit the formation of gastric ulcers caused by water immersion stress and hydrochloric acid damage. The ministerial drug rhubarb can also directly enhance intestinal peristalsis without affecting the absorption of nutrients in the small intestine. The purgative effect of rhubarb has been explained in the Dachengqi Decoction in the previous section. At the same time, the tannins contained in rhubarb have astringent and antidiarrheal effects. The purgative and astringent and antidiarrheal effects of rhubarb are mainly related to the length of decoction of rhubarb. If the decoction time is short, the purgative effect will be the main one, while if the decoction time is long, the astringent and antidiarrheal effect will be main.
Rhubarb can also promote bile secretion, strengthen gallbladder contraction, relax Oddi's sphincter, and increase bile acid secretion and bile flow. Rhubarb has obvious antibacterial activity against Bacteroides fragilis, an anaerobic bacterium that dominates the intestine. Normally, this bacterium only grows below the jejunum. In intestinal obstruction and intestinal paralysis, the anaerobic bacteria in the intestine rise and spread to the duodenum. Convert conjugated bile acid into free bile acid, which is toxic to mucous membranes and can easily cause cholecystitis. Therefore, rhubarb has a significant therapeutic effect on gallbladder infection and post-gallbladder surgery syndrome complicated infections, and can relieve gallbladder inflammation. colic. Rhubarb has a significant hemostatic effect on both internal and external bleeding. The single decoction is effective in treating upper gastrointestinal bleeding up to 96.7%, and it stops bleeding in an average of 2.2 days. Oral administration of rhubarb decoction has obvious hemostatic effect on acute necrotizing enteritis with bloody stool and mucus bloody stool. Therefore, it can be used for postoperative biliary bleeding. 11.6 Effects on nerve and endocrine functions
The monarch drug Aconite can adjust the body to a balanced state through its influence on central neurotransmitters; Aconite and the aconitum contained in it can increase the pain threshold and have significant It has analgesic effect, hypnotic and sedative effect at the same time, Aconitum and other anesthetic effects on peripheral nerves; more importantly, Aconite has an stimulating effect on the hypothalamus-pituitary-adrenocortical system. The ministerial drug rhubarb has antipsychotic effects as well as antipyretic and cooling effects. The adjuvant asarum volatile oil has significant antipyretic, sedative, and analgesic effects. Its analgesic degree is equivalent to that of antipyrine, and it can significantly increase the pain threshold. It is worth noting that asarum also has ALTH-like effects and enhances adrenocortical function. . Therefore, both aconite and asarum can increase the level of corticosteroids in the blood, which not only makes this prescription have powerful anti-inflammatory, antipyretic, and metabolic functions, but also its "allowing" effect is more conducive to coordinating the functions of other endocrine hormones in the body. Improve the body's adaptability and restore balance to neurological and endocrine functions, which is of great benefit to the treatment of its indications. 11.7 Effect on immune function
Junyao Fuzi Injection can significantly promote the increase in the number of spleen antibody-forming cells and the production of serum antibodies caused by SRBC immunity, and can increase the serum complement content and increase the rosette formation rate. and T lymphocyte transformation rate increased significantly. The ministerial drug rhubarb exerts various immunomodulatory effects on intestinal mucosal cells and brain cells, and protects bone marrow cells from damage by immunosuppressants. Rhubarb can significantly improve the immune function of infectious animal models and induce the production of interferon in the body. It can also significantly inhibit the secretion of cytokines by macrophages induced by endotoxin, which is enhanced with the increase of rhubarb concentration and action time. , while reducing the levels of TNFα and IL6 in plasma. Adjuvant Asarum water and ethanol extract can inhibit the release of immediate allergic reaction mediators, and also have a significant inhibitory effect on cellular immunity and humoral immunity. 12 Discussions by various schools
1. "Yizong Jinjian" quoted Zhang Lu: Dahuang Fuzi Decoction is a combination of cold and heat, combining hardness and softness. In modern times, people only know how to get cold, but they never know how to get warm. To cover up the hot knot caused by the sudden onset of cold, can the cold knot that has been accumulated for a long time also be brought down by cold? Rhubarb and Aconite Decoction uses asarum and aconite to attack cold knots under the ribs, that is, it combines the coldness of rhubarb to guide it. Use both cold and heat, warm and attack at the same time. This holy method is both obvious and inconceivable.
2. "Differentiation of Treatises on Febrile Diseases": Aconite warms the interior and unblocks yang, while Asarum warms the water internal organs and dispels the evil of cold and dampness. The liver and gallbladder have no way out, so rhubarb is used to use the stomach and intestines as a way out. The bitterness of rhubarb is combined with the bitterness of aconite and asarum. The combination of bitterness and pungency can reduce and relieve pain, and the general effect is not painful.
3. "Cheng Convenient Reading", Yin and cold gather together in one place. Although there is fever, it is also caused by the depression of Yang Qi. Therefore, the cold cannot be dissipated without warmth, and the accumulation cannot be removed without lowering, so the pungent heat of aconite and asarum can be used to remove it, and then rhubarb can be used to remove the accumulation. Human body surface area calculator BMI index calculation and evaluation Female safe period calculator Pregnancy date calculator Normal weight gain during pregnancy Safety classification of medication during pregnancy (FDA) Five elements and eight characters Adult blood pressure evaluation Body temperature level evaluation Diabetes diet recommendations Common clinical biochemistry units Conversion to basal metabolic rate Calculate sodium supplementation calculator Iron supplementation calculator Commonly used Latin abbreviations for prescription Quick check Common symbols for pharmacokinetics Quick check Effective plasma osmolality calculator Ethanol intake calculator
Medical encyclopedia, calculate now! 13 Notes
Rhubarb, Aconite and Asarum Decoction ("Wandering Miscellaneous Notes" cited in Volume 3 of "Jingui Yaolue"). 14 Song Jue
Rhubarb, Fuzi and Xixin Decoction is a prescription for cold condensation under the hypochondriac and hernia pain; cold accumulation in the body will form syndrome, and the cold syndrome can be restored by warming.
[2] 15 excerpts